CENPH_CHICK
ID CENPH_CHICK Reviewed; 235 AA.
AC Q90ZF9;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Centromere protein H;
DE Short=CENP-H;
GN Name=CENPH;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11500386; DOI=10.1093/emboj/20.16.4603;
RA Fukagawa T., Mikami Y., Nishihashi A., Regnier V., Haraguchi T.,
RA Hiraoka Y., Sugata N., Todokoro K., Brown W., Ikemura T.;
RT "CENP-H, a constitutive centromere component, is required for centromere
RT targeting of CENP-C in vertebrate cells.";
RL EMBO J. 20:4603-4617(2001).
RN [2]
RP INTERACTION WITH NDC80.
RX PubMed=15713649; DOI=10.1128/mcb.25.5.1958-1970.2005;
RA Mikami Y., Hori T., Kimura H., Fukagawa T.;
RT "The functional region of CENP-H interacts with the Nuf2 complex that
RT localizes to centromere during mitosis.";
RL Mol. Cell. Biol. 25:1958-1970(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN A COMPLEX WITH
RP CENPI; CENPK; CENPL; CENPM; CENPO AND CENPP.
RX PubMed=16622420; DOI=10.1038/ncb1396;
RA Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA Desai A., Fukagawa T.;
RT "The CENP-H-I complex is required for the efficient incorporation of newly
RT synthesized CENP-A into centromeres.";
RL Nat. Cell Biol. 8:446-457(2006).
CC -!- FUNCTION: Component of the CENPA-HI complex, a centromeric complex
CC involved in assembly of kinetochore proteins, mitotic progression and
CC chromosome segregation. Required for the localization of CENPC but not
CC CENPA to the centromere. It however may be involved in incorporation of
CC newly synthesized CENPA into centromeres via its interaction with the
CC CENPA-NAC complex. {ECO:0000269|PubMed:11500386}.
CC -!- SUBUNIT: Component of the CENPA-HI complex, at least composed of CENPH,
CC CENPI, CENPK, CENPL, CENPM, CENPO and CENPP. Interacts with NDC80.
CC {ECO:0000269|PubMed:15713649, ECO:0000269|PubMed:16622420}.
CC -!- INTERACTION:
CC Q90ZF9; Q76I89: NDC80; NbExp=5; IntAct=EBI-1003677, EBI-1003779;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11500386}.
CC Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11500386}.
CC Note=Associates with active centromere-kinetochore complexes throughout
CC the cell cycle.
CC -!- SIMILARITY: Belongs to the CENP-H/MCM16 family. {ECO:0000255}.
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DR EMBL; AB055783; BAB63439.1; -; mRNA.
DR RefSeq; NP_989942.1; NM_204611.1.
DR AlphaFoldDB; Q90ZF9; -.
DR SMR; Q90ZF9; -.
DR BioGRID; 675606; 9.
DR IntAct; Q90ZF9; 10.
DR STRING; 9031.ENSGALP00000032226; -.
DR PaxDb; Q90ZF9; -.
DR Ensembl; ENSGALT00000032863; ENSGALP00000032226; ENSGALG00000014788.
DR GeneID; 395316; -.
DR KEGG; gga:395316; -.
DR CTD; 64946; -.
DR VEuPathDB; HostDB:geneid_395316; -.
DR eggNOG; ENOG502S0VG; Eukaryota.
DR GeneTree; ENSGT00390000009578; -.
DR HOGENOM; CLU_097390_0_0_1; -.
DR InParanoid; Q90ZF9; -.
DR OMA; HRNVQYE; -.
DR OrthoDB; 1467214at2759; -.
DR PhylomeDB; Q90ZF9; -.
DR TreeFam; TF101134; -.
DR Reactome; R-GGA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-GGA-9648025; EML4 and NUDC in mitotic spindle formation.
DR PRO; PR:Q90ZF9; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000014788; Expressed in spermatid and 12 other tissues.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043515; F:kinetochore binding; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR InterPro; IPR040034; CENP-H.
DR InterPro; IPR008426; CENP-H_C.
DR PANTHER; PTHR48122; PTHR48122; 1.
DR Pfam; PF05837; CENP-H; 1.
PE 1: Evidence at protein level;
KW Centromere; Chromosome; Coiled coil; Kinetochore; Nucleus;
KW Reference proteome.
FT CHAIN 1..235
FT /note="Centromere protein H"
FT /id="PRO_0000249480"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..145
FT /evidence="ECO:0000255"
SQ SEQUENCE 235 AA; 26800 MW; 26808B7C1C8A4AC3 CRC64;
MAGRLSESVG SGPGAEAETA ADPDAKRDVL EHLCARTHLK QLVMEFDTAC PPDEGCNSGA
EVNFIESAKE TLEEVGKVKS AFESKALVIK RIQLMDALRK RVKENDGCAR LIVETMRDII
KLNWEIIQAH QQARVIRENL NDIRRKRYFL KQAEGEKALR IFTTVRKKKE VVRMKIAEKL
KFIHRNVQYE RKVTTLVQNI LQNIIVGCQI NWAKDPSLRA IILQLEKDIS IQNLL