CENPH_HUMAN
ID CENPH_HUMAN Reviewed; 247 AA.
AC Q9H3R5; A8K3Y1;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Centromere protein H;
DE Short=CENP-H;
DE AltName: Full=Interphase centromere complex protein 35;
GN Name=CENPH {ECO:0000312|HGNC:HGNC:17268}; Synonyms=ICEN35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB18635.1}
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH KIF2C, AND SUBCELLULAR
RP LOCATION.
RC TISSUE=Cervix carcinoma;
RX PubMed=11092768; DOI=10.1093/hmg/9.19.2919;
RA Sugata N., Li S., Earnshaw W.C., Yen T.J., Yoda K., Masumoto H.,
RA Munekata E., Warburton P.E., Todokoro K.;
RT "Human CENP-H multimers colocalize with CENP-A and CENP-C at active
RT centromere-kinetochore complexes.";
RL Hum. Mol. Genet. 9:2919-2926(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH15355.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta {ECO:0000312|EMBL:AAH15355.1}, and
RC Testis {ECO:0000312|EMBL:AAH12024.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=14536089; DOI=10.1016/s1097-2765(03)00279-x;
RA Saffery R., Sumer H., Hassan S., Wong L.H., Craig J.M., Todokoro K.,
RA Anderson M., Stafford A., Choo K.H.A.;
RT "Transcription within a functional human centromere.";
RL Mol. Cell 12:509-516(2003).
RN [6]
RP INTERACTION WITH NDC80.
RX PubMed=15713649; DOI=10.1128/mcb.25.5.1958-1970.2005;
RA Mikami Y., Hori T., Kimura H., Fukagawa T.;
RT "The functional region of CENP-H interacts with the Nuf2 complex that
RT localizes to centromere during mitosis.";
RL Mol. Cell. Biol. 25:1958-1970(2005).
RN [7]
RP FUNCTION.
RX PubMed=16875666; DOI=10.1016/j.bbrc.2006.06.187;
RA Orthaus S., Ohndorf S., Diekmann S.;
RT "RNAi knockdown of human kinetochore protein CENP-H.";
RL Biochem. Biophys. Res. Commun. 348:36-46(2006).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=16716197; DOI=10.1111/j.1365-2443.2006.00969.x;
RA Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y.,
RA Goshima N., Nomura F., Nomura N., Yoda K.;
RT "Comprehensive analysis of the ICEN (Interphase Centromere Complex)
RT components enriched in the CENP-A chromatin of human cells.";
RL Genes Cells 11:673-684(2006).
RN [9]
RP IDENTIFICATION IN A COMPLEX WITH CENPI; CENPK; CENPN; CENPO; CENPP; CENPQ;
RP CENPR AND CENPU.
RX PubMed=16622420; DOI=10.1038/ncb1396;
RA Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA Desai A., Fukagawa T.;
RT "The CENP-H-I complex is required for the efficient incorporation of newly
RT synthesized CENP-A into centromeres.";
RL Nat. Cell Biol. 8:446-457(2006).
RN [10]
RP IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPM; CENPN;
RP CENPT AND CENPU.
RX PubMed=16622419; DOI=10.1038/ncb1397;
RA Foltz D.R., Jansen L.E.T., Black B.E., Bailey A.O., Yates J.R. III,
RA Cleveland D.W.;
RT "The human CENP-A centromeric nucleosome-associated complex.";
RL Nat. Cell Biol. 8:458-469(2006).
RN [11]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18007590; DOI=10.1038/sj.emboj.7601927;
RA McClelland S.E., Borusu S., Amaro A.C., Winter J.R., Belwal M.,
RA McAinsh A.D., Meraldi P.;
RT "The CENP-A NAC/CAD kinetochore complex controls chromosome congression and
RT spindle bipolarity.";
RL EMBO J. 26:5033-5047(2007).
RN [12]
RP SUBCELLULAR LOCATION.
RX PubMed=17651496; DOI=10.1186/gb-2007-8-7-r148;
RA Alonso A., Fritz B., Hasson D., Abrusan G., Cheung F., Yoda K.,
RA Radlwimmer B., Ladurner A.G., Warburton P.E.;
RT "Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A
RT chromatin at human neocentromeres.";
RL Genome Biol. 8:R148.1-R148.19(2007).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [14]
RP INTERACTION WITH CENPK.
RX PubMed=19381461; DOI=10.1007/s11427-009-0050-3;
RA Qiu S., Wang J., Yu C., He D.;
RT "CENP-K and CENP-H may form coiled-coils in the kinetochores.";
RL Sci. China, Ser. C, Life Sci. 52:352-359(2009).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND THR-68, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [17]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-67, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [18]
RP VARIANT [LARGE SCALE ANALYSIS] LYS-2.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a
CC complex that plays a central role in assembly of kinetochore proteins,
CC mitotic progression and chromosome segregation. The CENPA-NAC complex
CC recruits the CENPA-CAD (nucleosome distal) complex and may be involved
CC in incorporation of newly synthesized CENPA into centromeres. Required
CC for chromosome congression and efficiently align the chromosomes on a
CC metaphase plate. {ECO:0000269|PubMed:14536089,
CC ECO:0000269|PubMed:16875666, ECO:0000269|PubMed:18007590}.
CC -!- SUBUNIT: Self-associates. Component of the CENPA-NAC complex, at least
CC composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The
CC CENPA-NAC complex interacts with the CENPA-CAD complex, composed of
CC CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts
CC directly with CENPK. Interacts with KIF2C and NDC80. Interacts with
CC TRIM36 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H3R5; Q9NYB9-2: ABI2; NbExp=6; IntAct=EBI-1003700, EBI-11096309;
CC Q9H3R5; P61158: ACTR3; NbExp=3; IntAct=EBI-1003700, EBI-351428;
CC Q9H3R5; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-1003700, EBI-747505;
CC Q9H3R5; Q7Z758: C8orf58; NbExp=3; IntAct=EBI-1003700, EBI-13286880;
CC Q9H3R5; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-1003700, EBI-10749669;
CC Q9H3R5; Q9BS16: CENPK; NbExp=7; IntAct=EBI-1003700, EBI-6871750;
CC Q9H3R5; P28329-3: CHAT; NbExp=3; IntAct=EBI-1003700, EBI-25837549;
CC Q9H3R5; Q13561: DCTN2; NbExp=5; IntAct=EBI-1003700, EBI-715074;
CC Q9H3R5; P84090: ERH; NbExp=3; IntAct=EBI-1003700, EBI-711389;
CC Q9H3R5; P22607: FGFR3; NbExp=3; IntAct=EBI-1003700, EBI-348399;
CC Q9H3R5; O75409: H2AP; NbExp=3; IntAct=EBI-1003700, EBI-6447217;
CC Q9H3R5; P01112: HRAS; NbExp=3; IntAct=EBI-1003700, EBI-350145;
CC Q9H3R5; P20700: LMNB1; NbExp=3; IntAct=EBI-1003700, EBI-968218;
CC Q9H3R5; Q14696: MESD; NbExp=3; IntAct=EBI-1003700, EBI-6165891;
CC Q9H3R5; Q13126: MTAP; NbExp=3; IntAct=EBI-1003700, EBI-2547776;
CC Q9H3R5; O14777: NDC80; NbExp=6; IntAct=EBI-1003700, EBI-715849;
CC Q9H3R5; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-1003700, EBI-741048;
CC Q9H3R5; Q9H2L5: RASSF4; NbExp=3; IntAct=EBI-1003700, EBI-2933362;
CC Q9H3R5; Q96R06: SPAG5; NbExp=3; IntAct=EBI-1003700, EBI-413317;
CC Q9H3R5; Q6ZR52-3: ZNF493; NbExp=3; IntAct=EBI-1003700, EBI-12856290;
CC Q9H3R5; O43309: ZSCAN12; NbExp=3; IntAct=EBI-1003700, EBI-1210440;
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore.
CC Note=Associates with active centromere-kinetochore complexes throughout
CC the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA
CC and CENPC during both interphase and metaphase.
CC -!- SIMILARITY: Belongs to the CENP-H/MCM16 family. {ECO:0000255}.
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DR EMBL; AB035124; BAB18635.1; -; mRNA.
DR EMBL; AK290746; BAF83435.1; -; mRNA.
DR EMBL; CH471137; EAW51304.1; -; Genomic_DNA.
DR EMBL; BC015355; AAH15355.1; -; mRNA.
DR EMBL; BC012024; AAH12024.1; -; mRNA.
DR CCDS; CCDS3998.1; -.
DR RefSeq; NP_075060.1; NM_022909.3.
DR AlphaFoldDB; Q9H3R5; -.
DR SMR; Q9H3R5; -.
DR BioGRID; 122355; 88.
DR ComplexPortal; CPX-5646; Kinetochore CCAN complex.
DR CORUM; Q9H3R5; -.
DR IntAct; Q9H3R5; 56.
DR MINT; Q9H3R5; -.
DR STRING; 9606.ENSP00000283006; -.
DR iPTMnet; Q9H3R5; -.
DR PhosphoSitePlus; Q9H3R5; -.
DR BioMuta; CENPH; -.
DR DMDM; 74733576; -.
DR EPD; Q9H3R5; -.
DR jPOST; Q9H3R5; -.
DR MassIVE; Q9H3R5; -.
DR MaxQB; Q9H3R5; -.
DR PaxDb; Q9H3R5; -.
DR PeptideAtlas; Q9H3R5; -.
DR PRIDE; Q9H3R5; -.
DR ProteomicsDB; 80745; -.
DR Antibodypedia; 23919; 403 antibodies from 30 providers.
DR DNASU; 64946; -.
DR Ensembl; ENST00000283006.7; ENSP00000283006.2; ENSG00000153044.10.
DR GeneID; 64946; -.
DR KEGG; hsa:64946; -.
DR MANE-Select; ENST00000283006.7; ENSP00000283006.2; NM_022909.4; NP_075060.1.
DR UCSC; uc003jvp.3; human.
DR CTD; 64946; -.
DR DisGeNET; 64946; -.
DR GeneCards; CENPH; -.
DR HGNC; HGNC:17268; CENPH.
DR HPA; ENSG00000153044; Tissue enhanced (bone marrow, testis).
DR MIM; 605607; gene.
DR neXtProt; NX_Q9H3R5; -.
DR OpenTargets; ENSG00000153044; -.
DR PharmGKB; PA26402; -.
DR VEuPathDB; HostDB:ENSG00000153044; -.
DR eggNOG; ENOG502S0VG; Eukaryota.
DR GeneTree; ENSGT00390000009578; -.
DR InParanoid; Q9H3R5; -.
DR OMA; KSHQESW; -.
DR OrthoDB; 1467214at2759; -.
DR PhylomeDB; Q9H3R5; -.
DR TreeFam; TF101134; -.
DR PathwayCommons; Q9H3R5; -.
DR Reactome; R-HSA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-HSA-2467813; Separation of Sister Chromatids.
DR Reactome; R-HSA-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-HSA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR Reactome; R-HSA-68877; Mitotic Prometaphase.
DR Reactome; R-HSA-9648025; EML4 and NUDC in mitotic spindle formation.
DR SignaLink; Q9H3R5; -.
DR SIGNOR; Q9H3R5; -.
DR BioGRID-ORCS; 64946; 429 hits in 1049 CRISPR screens.
DR ChiTaRS; CENPH; human.
DR GeneWiki; CENPH; -.
DR GenomeRNAi; 64946; -.
DR Pharos; Q9H3R5; Tbio.
DR PRO; PR:Q9H3R5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9H3R5; protein.
DR Bgee; ENSG00000153044; Expressed in ventricular zone and 119 other tissues.
DR ExpressionAtlas; Q9H3R5; baseline and differential.
DR Genevisible; Q9H3R5; HS.
DR GO; GO:0005694; C:chromosome; IDA:HPA.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0000776; C:kinetochore; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0043515; F:kinetochore binding; IDA:UniProtKB.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR GO; GO:0051383; P:kinetochore organization; TAS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR InterPro; IPR040034; CENP-H.
DR InterPro; IPR008426; CENP-H_C.
DR PANTHER; PTHR48122; PTHR48122; 1.
DR Pfam; PF05837; CENP-H; 1.
PE 1: Evidence at protein level;
KW Acetylation; Centromere; Chromosome; Coiled coil; Isopeptide bond;
KW Kinetochore; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..247
FT /note="Centromere protein H"
FT /id="PRO_0000089478"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..192
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:22814378"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 68
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 67
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 2
FT /note="E -> K (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs777698677)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036167"
SQ SEQUENCE 247 AA; 28481 MW; E1BCD4022710168F CRC64;
MEEQPQMQDA DEPADSGGEG RAGGPPQVAG AQAACSEDRM TLLLRLRAQT KQQLLEYKSM
VDASEEKTPE QIMQEKQIEA KIEDLENEIE EVKVAFEIKK LALDRMRLST ALKKNLEKIS
RQSSVLMDNM KHLLELNKLI MKSQQESWDL EEKLLDIRKK RLQLKQASES KLLEIQTEKN
KQKIDLDSME NSERIKIIRQ NLQMEIKITT VIQHVFQNLI LGSKVNWAED PALKEIVLQL
EKNVDMM
