ID   CENPH_SCHPO             Reviewed;         220 AA.
AC   O94261;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Inner kinetochore subunit fta3;
DE   AltName: Full=CENP-H homolog;
DE   AltName: Full=Constitutive centromere-associated network protein fta3;
DE   AltName: Full=Sim4 complex subunit fta3;
DE   AltName: Full=Sim4-mal2-associated protein 3;
GN   Name=fta3; Synonyms=sma3; ORFNames=SPBP8B7.12c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA   Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT   "Molecular analysis of kinetochore architecture in fission yeast.";
RL   EMBO J. 24:2919-2930(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC       assembles on centromeric DNA and attaches chromosomes to spindle
CC       microtubules, mediating chromosome segregation and sister chromatid
CC       segregation during meiosis and mitosis. Component of the inner
CC       kinetochore constitutive centromere-associated network (CCAN), which
CC       serves as a structural platform for outer kinetochore assembly (By
CC       similarity). Fta2, fta3 and fta4 associate with the central core (cnt)
CC       and inner repeat (inr) region of the centromere (PubMed:16079914).
CC       {ECO:0000250|UniProtKB:P43618, ECO:0000269|PubMed:16079914}.
CC   -!- SUBUNIT: Component of the inner kinetochore constitutive centromere-
CC       associated network (CCAN) (also known as central kinetochore Sim4
CC       complex in fission yeast), which is composed of at least cnl2, cnp3,
CC       cnp20, fta1, fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6,
CC       mis15, mis17, sim4 and wip1. {ECO:0000269|PubMed:16079914}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore.
CC   -!- SIMILARITY: Belongs to the CENP-H/MCM16 family. {ECO:0000255}.
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DR   EMBL; CU329671; CAA21797.1; -; Genomic_DNA.
DR   PIR; T40806; T40806.
DR   RefSeq; NP_596519.1; NM_001022440.2.
DR   AlphaFoldDB; O94261; -.
DR   SMR; O94261; -.
DR   BioGRID; 277853; 5.
DR   STRING; 4896.SPBP8B7.12c.1; -.
DR   PaxDb; O94261; -.
DR   EnsemblFungi; SPBP8B7.12c.1; SPBP8B7.12c.1:pep; SPBP8B7.12c.
DR   PomBase; SPBP8B7.12c; fta3.
DR   VEuPathDB; FungiDB:SPBP8B7.12c; -.
DR   HOGENOM; CLU_1235669_0_0_1; -.
DR   OMA; QREDRTY; -.
DR   PRO; PR:O94261; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IC:PomBase.
DR   InterPro; IPR008426; CENP-H_C.
DR   Pfam; PF05837; CENP-H; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Kinetochore; Microtubule; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..220
FT                   /note="Inner kinetochore subunit fta3"
FT                   /id="PRO_0000290639"
SQ   SEQUENCE   220 AA;  24997 MW;  C774FC46E6053FF3 CRC64;
     MDNNDQISNL CLGALQLLAD QPISVISNEP SEEQRNEHVL KKWENNVLRH WKILFSLFMQ
     TCGDSVQGNA AFSILNFMTT NSLVGQLYQR LYDESNSLGF ISSPLNETEH LSEENLKIES
     SITFTSEEIE KEKENIKSVL LPSVQSISSS LELYASKESD YRSSIEGVLA DLKLARARWE
     IVRNVTQILL LESGISFLEN KKLAYIMDLC GDREDNYSSY