ID   CENPK_CHICK             Reviewed;         260 AA.
AC   Q1T7C1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Centromere protein K;
DE            Short=CENP-K;
GN   Name=CENPK;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPL; CENPM; CENPO AND
RP   CENPP.
RX   PubMed=16622420; DOI=10.1038/ncb1396;
RA   Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA   Desai A., Fukagawa T.;
RT   "The CENP-H-I complex is required for the efficient incorporation of newly
RT   synthesized CENP-A into centromeres.";
RL   Nat. Cell Biol. 8:446-457(2006).
CC   -!- FUNCTION: Component of the CENPA-HI complex, a centromeric complex
CC       involved in assembly of kinetochore proteins, mitotic progression and
CC       chromosome segregation. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CENPA-HI complex, at least composed of CENPH,
CC       CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
CC       {ECO:0000269|PubMed:16622420}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC       Note=Localizes exclusively in the centromeres. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-K/MCM22 family. {ECO:0000305}.
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DR   EMBL; AB231847; BAE93412.1; -; mRNA.
DR   RefSeq; NP_001038128.1; NM_001044663.1.
DR   RefSeq; XP_015132796.1; XM_015277310.1.
DR   AlphaFoldDB; Q1T7C1; -.
DR   SMR; Q1T7C1; -.
DR   BioGRID; 686517; 2.
DR   IntAct; Q1T7C1; 1.
DR   STRING; 9031.ENSGALP00000023743; -.
DR   PRIDE; Q1T7C1; -.
DR   GeneID; 427162; -.
DR   KEGG; gga:427162; -.
DR   CTD; 64105; -.
DR   VEuPathDB; HostDB:geneid_427162; -.
DR   eggNOG; ENOG502QVGW; Eukaryota.
DR   HOGENOM; CLU_090360_0_0_1; -.
DR   InParanoid; Q1T7C1; -.
DR   PhylomeDB; Q1T7C1; -.
DR   PRO; PR:Q1T7C1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   InterPro; IPR020993; Centromere_CenpK.
DR   PANTHER; PTHR14401; PTHR14401; 1.
DR   Pfam; PF11802; CENP-K; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; Coiled coil; Kinetochore; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..260
FT                   /note="Centromere protein K"
FT                   /id="PRO_0000249484"
FT   COILED          84..173
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  30720 MW;  3E297EF9D1500495 CRC64;
     MSDSVCPIDA KEELLRECEN IWKEMEKCQS KLTLLAAEPV PESDAKVSLL LTRMQALRAE
     YHQWQKRNPE LISTNPEVLL LLGEEELQKV KKELEMVLSA VQLKNEKLKE DLEREQQWHD
     EQVQILNAFK EIEEEMKKEV VTDSEKRVFQ ELKNQMLELK EYKKKLMNAL GEFLEEHFPL
     PEKNGNAKKK RYSEEPPEQV ITIHEILEIL LNQLMSTPHE PYVTVDDSFW PPYLELLLRS
     GIVLRHPEDP NRIRLEAFHE