ID   CENPK_XENLA             Reviewed;         274 AA.
AC   Q5XGL1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Centromere protein K;
DE            Short=CENP-K;
GN   Name=cenpk;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC       Note=Localizes exclusively in the centromeres. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-K/MCM22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH84426.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC084426; AAH84426.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001088353.1; NM_001094884.1.
DR   AlphaFoldDB; Q5XGL1; -.
DR   SMR; Q5XGL1; -.
DR   DNASU; 495196; -.
DR   GeneID; 495196; -.
DR   KEGG; xla:495196; -.
DR   CTD; 495196; -.
DR   Xenbase; XB-GENE-17337946; cenpk.L.
DR   OrthoDB; 1051530at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 495196; Expressed in testis and 19 other tissues.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   InterPro; IPR020993; Centromere_CenpK.
DR   PANTHER; PTHR14401; PTHR14401; 1.
DR   Pfam; PF11802; CENP-K; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Coiled coil; Kinetochore; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..274
FT                   /note="Centromere protein K"
FT                   /id="PRO_0000249485"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          96..159
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   274 AA;  31888 MW;  6F0F63CB17258DDD CRC64;
     MSGYQHELPP NISKTSPAPE EAREELLQQC EAIWKQMEEC QSKLTMSGPE TLPETDVQLY
     LLMMQVKALT AEYEQWQKRT PEIISDNQDV LLAVGKEELE KIAQELEMVL SSVQAKNKKL
     KKDLEKEQNW LDGQQKIVDA LTSRQDELKN QLTAFSEKRV YQDIAGKLYK VRAHKEELLS
     ALGDFLEEHF PLPQEQENQS KKKKGQSGKK SVQLMTLHEI LEILINKLMT TPHDPYLVLE
     PHHWPPYIEM LLRYGIALRH PEDPKRIRLE AFHQ