ID   CENPL_BOVIN             Reviewed;         346 AA.
AC   Q5EA18; A0JNC6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Centromere protein L;
DE            Short=CENP-L;
GN   Name=CENPL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC       complex recruited to centromeres which is involved in assembly of
CC       kinetochore proteins, mitotic progression and chromosome segregation.
CC       May be involved in incorporation of newly synthesized CENPA into
CC       centromeres via its interaction with the CENPA-NAC complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC       CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC       interacts with the CENPA-NAC complex, at least composed of CENPA,
CC       CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres. The
CC       CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
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DR   EMBL; BT020751; AAX08768.1; -; mRNA.
DR   EMBL; BC126617; AAI26618.1; -; mRNA.
DR   RefSeq; NP_001029954.1; NM_001034782.1.
DR   RefSeq; XP_010811661.1; XM_010813359.2.
DR   AlphaFoldDB; Q5EA18; -.
DR   STRING; 9913.ENSBTAP00000009094; -.
DR   PaxDb; Q5EA18; -.
DR   PRIDE; Q5EA18; -.
DR   Ensembl; ENSBTAT00000009094; ENSBTAP00000009094; ENSBTAG00000006925.
DR   GeneID; 615527; -.
DR   KEGG; bta:615527; -.
DR   CTD; 91687; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006925; -.
DR   VGNC; VGNC:27180; CENPL.
DR   eggNOG; ENOG502QS38; Eukaryota.
DR   GeneTree; ENSGT00390000013877; -.
DR   HOGENOM; CLU_070598_0_0_1; -.
DR   InParanoid; Q5EA18; -.
DR   OMA; TACKMDQ; -.
DR   OrthoDB; 1179445at2759; -.
DR   TreeFam; TF329688; -.
DR   Reactome; R-BTA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000006925; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025204; CENP-L.
DR   PANTHER; PTHR31740; PTHR31740; 1.
DR   Pfam; PF13092; CENP-L; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Centromere protein L"
FT                   /id="PRO_0000247169"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0S6"
FT   MOD_RES         45
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0S6"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0S6"
SQ   SEQUENCE   346 AA;  39422 MW;  2F9EE1CC23D6DE7D CRC64;
     MDSYDAPELT PRQDASSRLK DFFVGATPLQ KRLESVRKQT SFIPTPPRRK IPQGSQLQED
     VDPQKFAFLL HKQWTLYSLT PLYKFSYTNF KEYSKLLNAF IAAEKQKGLA VEVGDDFNIK
     VVFSTLMGVK GTQRDPEAFL VQILSKSQLP SEHKEGKVLW TGWFCCVFGD SLLETVSEDF
     TCLPLFLVNG AETNTAIIGT WFQKTFDCYF RPLAINAFNL SWMAAMWTAC KMDHYMATTE
     FLWSVPCSPH SLDISYAIHP EDAKALWDSV HKTPGEVTQE EVDLFMDCLY SHFHRHFKIH
     LSATRLVRVS TSVASAHTDG KIKILCPKYL IGVLAYLTEL AVFQIE