ID   CENPL_CHICK             Reviewed;         344 AA.
AC   Q1T7C0; Q5ZKV0;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Centromere protein L;
DE            Short=CENP-L;
GN   Name=CENPL; ORFNames=RCJMB04_9b13;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPM; CENPO AND
RP   CENPP.
RX   PubMed=16622420; DOI=10.1038/ncb1396;
RA   Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA   Desai A., Fukagawa T.;
RT   "The CENP-H-I complex is required for the efficient incorporation of newly
RT   synthesized CENP-A into centromeres.";
RL   Nat. Cell Biol. 8:446-457(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the CENPA-HI complex, a centromeric complex
CC       involved in assembly of kinetochore proteins, mitotic progression and
CC       chromosome segregation. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CENPA-HI complex, at least composed of CENPH,
CC       CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
CC       {ECO:0000269|PubMed:16622420}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, centromere
CC       {ECO:0000305}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
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DR   EMBL; AB231848; BAE93413.1; -; mRNA.
DR   EMBL; AJ719984; CAG31643.1; -; mRNA.
DR   RefSeq; NP_001006569.2; NM_001006569.3.
DR   AlphaFoldDB; Q1T7C0; -.
DR   BioGRID; 686144; 2.
DR   IntAct; Q1T7C0; 1.
DR   STRING; 9031.ENSGALP00000043253; -.
DR   Ensembl; ENSGALT00000085107; ENSGALP00000062160; ENSGALG00000038411.
DR   GeneID; 426563; -.
DR   KEGG; gga:426563; -.
DR   CTD; 91687; -.
DR   VEuPathDB; HostDB:geneid_426563; -.
DR   eggNOG; ENOG502QS38; Eukaryota.
DR   GeneTree; ENSGT00390000013877; -.
DR   InParanoid; Q1T7C0; -.
DR   OMA; TACKMDQ; -.
DR   OrthoDB; 1179445at2759; -.
DR   PhylomeDB; Q1T7C0; -.
DR   Reactome; R-GGA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR   Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-GGA-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q1T7C0; -.
DR   Proteomes; UP000000539; Chromosome 8.
DR   Bgee; ENSGALG00000038411; Expressed in spermatid and 5 other tissues.
DR   ExpressionAtlas; Q1T7C0; baseline and differential.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025204; CENP-L.
DR   PANTHER; PTHR31740; PTHR31740; 1.
DR   Pfam; PF13092; CENP-L; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; Nucleus; Reference proteome.
FT   CHAIN           1..344
FT                   /note="Centromere protein L"
FT                   /id="PRO_0000249486"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        104
FT                   /note="Q -> R (in Ref. 2; CAG31643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        117
FT                   /note="I -> V (in Ref. 2; CAG31643)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   344 AA;  37893 MW;  AF3BA832A0DFD1BD CRC64;
     MAGGRPAGSA IEMEGAMRTL PSSGRPSGTG WQSRGPLFGR NYGLSPGSRL LPPRCQENAD
     PQKMAFLLRK QWTLYSVSPL YKFSSADLKD YARMLGVFIA AEKQKGLAVD VDGELGIKVA
     MSGLPELRGS EQDPAAVLVQ LSLRSSVSPK NSEEKLIWSG WFCCVAGDDL LENLPENFTC
     LPLFLVNGAE SYTAIVGSWF QKTFDCCFRR LAISPLNLTW MAAMWTGCKV DKNTAATELL
     FSVPHLPQPL DISYAIHPED AKALWDTVQK TPGEITQEEV DVFMECLYSH FHRHFKIHLS
     ATKLVKVSTG IASAHCDGII KFLQSQYLIG VLMLLTELAI SQIQ