ID   CENPL_DANRE             Reviewed;         367 AA.
AC   Q6DRD4; Q502U4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Centromere protein L;
DE            Short=CENP-L;
GN   Name=cenpl;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95551.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY648825; AAT68143.1; -; mRNA.
DR   EMBL; BC095551; AAH95551.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; Q6DRD4; -.
DR   STRING; 7955.ENSDARP00000056666; -.
DR   PaxDb; Q6DRD4; -.
DR   ZFIN; ZDB-GENE-040930-6; cenpl.
DR   eggNOG; ENOG502QS38; Eukaryota.
DR   InParanoid; Q6DRD4; -.
DR   PhylomeDB; Q6DRD4; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q6DRD4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025204; CENP-L.
DR   PANTHER; PTHR31740; PTHR31740; 1.
DR   Pfam; PF13092; CENP-L; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Reference proteome.
FT   CHAIN           1..367
FT                   /note="Centromere protein L"
FT                   /id="PRO_0000249487"
FT   CONFLICT        224
FT                   /note="F -> S (in Ref. 2; AAH95551)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        230
FT                   /note="S -> P (in Ref. 2; AAH95551)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        290
FT                   /note="Q -> E (in Ref. 2; AAH95551)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   367 AA;  40637 MW;  E540853EA7A2D0F7 CRC64;
     MFNLLPAFSL GVLLIVMEGR GSAVNTPASR PVTRKSKSYG RSCVEAPSYF WQTPGHLTVL
     KVPTSRGAAK SQIITNKVDP EHIALLVKNE WKLSYVTPLH HFRHTQLKSY AKHLSAFIVA
     EKQQGVAVEV GLDAGFKVTF TAVLGLAETD EDAETVFIQI QSKPVFAAAA DAPKVVWRGW
     LTCVNGDPEY LRSLPPDFVS LPLFCTSGPE SLTNLVKSWF ERAFDCNFGS LALNSSTLNW
     LAALWTGCHP ACNIRYLKLS WSLPTEPPLD VLYTVNPQDA WELWNSIHPQ ENTDDRIDIK
     DVQAFMSGME THFFRHFKIH LSAGTLLKVS TALGSAHHDG KIKIGNSDYI TTLLALLTEC
     ALLKMPT