CENPL_MOUSE
ID CENPL_MOUSE Reviewed; 329 AA.
AC Q3U3S3; E9QKF0; Q9CSU9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Centromere protein L;
DE Short=CENP-L;
GN Name=Cenpl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Dendritic cell, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC complex recruited to centromeres which is involved in assembly of
CC kinetochore proteins, mitotic progression and chromosome segregation.
CC May be involved in incorporation of newly synthesized CENPA into
CC centromeres via its interaction with the CENPA-NAC complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC interacts with the CENPA-NAC complex, at least composed of CENPA,
CC CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC {ECO:0000250}. Note=Localizes exclusively in the centromeres. The
CC CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC
CC complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
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DR EMBL; AK011942; BAB27928.3; -; mRNA.
DR EMBL; AK154611; BAE32712.1; -; mRNA.
DR EMBL; AC138640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q3U3S3; -.
DR ComplexPortal; CPX-5704; Kinetochore CCAN complex.
DR STRING; 10090.ENSMUSP00000107247; -.
DR iPTMnet; Q3U3S3; -.
DR PhosphoSitePlus; Q3U3S3; -.
DR MaxQB; Q3U3S3; -.
DR PaxDb; Q3U3S3; -.
DR PRIDE; Q3U3S3; -.
DR ProteomicsDB; 281582; -.
DR Antibodypedia; 47079; 72 antibodies from 23 providers.
DR Ensembl; ENSMUST00000028035; ENSMUSP00000028035; ENSMUSG00000026708.
DR UCSC; uc007dfe.3; mouse.
DR MGI; MGI:1917704; Cenpl.
DR VEuPathDB; HostDB:ENSMUSG00000026708; -.
DR eggNOG; ENOG502QS38; Eukaryota.
DR GeneTree; ENSGT00390000013877; -.
DR InParanoid; Q3U3S3; -.
DR Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-MMU-2467813; Separation of Sister Chromatids.
DR Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
DR Reactome; R-MMU-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR Reactome; R-MMU-68877; Mitotic Prometaphase.
DR Reactome; R-MMU-9648025; EML4 and NUDC in mitotic spindle formation.
DR PRO; PR:Q3U3S3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3U3S3; protein.
DR Bgee; ENSMUSG00000026708; Expressed in manus and 152 other tissues.
DR ExpressionAtlas; Q3U3S3; baseline and differential.
DR Genevisible; Q3U3S3; MM.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR025204; CENP-L.
DR PANTHER; PTHR31740; PTHR31740; 1.
DR Pfam; PF13092; CENP-L; 1.
PE 2: Evidence at transcript level;
KW Centromere; Chromosome; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..329
FT /note="Centromere protein L"
FT /id="PRO_0000247171"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N0S6"
FT MOD_RES 54
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N0S6"
FT CONFLICT 36
FT /note="R -> K (in Ref. 1; BAE32712)"
FT /evidence="ECO:0000305"
FT CONFLICT 328..329
FT /note="SN -> P (in Ref. 1; BAB27928)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 37725 MW; 0EB2DB87F679CFC8 CRC64;
MDSCDFRGLT SRRRTSNLKN YFVGATPLQK RLELVRRQNS DFPSPSRRKI PQCSQLQEDI
DPQKVAFLLH KQWTIYSLTP LYKFSYSNLK DYSRLLSAFI VAEKQKGVAV EVGEDFNIKV
IFSTLLGVKG TQRDHEAFLV QILSKSQSSR EHREDKVLWT GWFCCVFGES LQETVSEDFT
CLPLFLANGA ESNTSLIRDW FQKTFDCCFS PLAISAFNLS WMAAMWTACK MDRYMATTEF
LWSVPCSPQS LDISYAIHPE DAKALWESVH KTPGEVTQEE VDLFMNCLYS HFHRHFKIHL
AATRLVRVST SVASAHTDGK IKVSLNRSN
