ID   CENPL_RAT               Reviewed;         345 AA.
AC   Q3ZAU7; Q0P5Q6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Centromere protein L;
DE            Short=CENP-L;
GN   Name=Cenpl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC       complex recruited to centromeres which is involved in assembly of
CC       kinetochore proteins, mitotic progression and chromosome segregation.
CC       May be involved in incorporation of newly synthesized CENPA into
CC       centromeres via its interaction with the CENPA-NAC complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC       CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC       interacts with the CENPA-NAC complex, at least composed of CENPA,
CC       CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres. The
CC       CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
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DR   EMBL; BC079467; AAH79467.1; -; mRNA.
DR   EMBL; BC103642; AAI03643.1; -; mRNA.
DR   RefSeq; NP_001028233.2; NM_001033061.2.
DR   RefSeq; NP_001231690.1; NM_001244761.1.
DR   AlphaFoldDB; Q3ZAU7; -.
DR   STRING; 10116.ENSRNOP00000056033; -.
DR   iPTMnet; Q3ZAU7; -.
DR   PhosphoSitePlus; Q3ZAU7; -.
DR   PaxDb; Q3ZAU7; -.
DR   GeneID; 289150; -.
DR   KEGG; rno:289150; -.
DR   UCSC; RGD:1311868; rat.
DR   CTD; 91687; -.
DR   RGD; 1311868; Cenpl.
DR   VEuPathDB; HostDB:ENSRNOG00000038789; -.
DR   eggNOG; ENOG502QS38; Eukaryota.
DR   HOGENOM; CLU_070598_0_0_1; -.
DR   InParanoid; Q3ZAU7; -.
DR   OrthoDB; 1179445at2759; -.
DR   PhylomeDB; Q3ZAU7; -.
DR   TreeFam; TF329688; -.
DR   Reactome; R-RNO-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR   Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-RNO-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-RNO-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-RNO-68877; Mitotic Prometaphase.
DR   Reactome; R-RNO-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q3ZAU7; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000038789; Expressed in thymus and 19 other tissues.
DR   ExpressionAtlas; Q3ZAU7; baseline and differential.
DR   Genevisible; Q3ZAU7; RN.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025204; CENP-L.
DR   PANTHER; PTHR31740; PTHR31740; 1.
DR   Pfam; PF13092; CENP-L; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Centromere protein L"
FT                   /id="PRO_0000247172"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0S6"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0S6"
SQ   SEQUENCE   345 AA;  39460 MW;  B04985CCB7BCE3AD CRC64;
     MDTYDSQGPT SRRRTSNLKD YFVSATPLQK RLKLARRQSS VFPSPSRRKI PQCSQLQEDI
     DPQKVAFLLH KQWTVYSLTP LYKFSYSNLK DYSRLLSAFI AAEKQKGLAV EVGEDFNIKV
     IFSTLLGVKG TQRDPEAFLV QIRSESQSSR EHRQDKVLWT GWFCCVFGEN LQETVSEDFT
     CLPLFLAHGA ESNTSLIGGW FQKTFDCCFS PLAISAFNLS WMAAMWTACK MDHYMATTEF
     FWSVPCSPQS LDISYAIHPE DAKALWDSVH KTPGEVTQEE VDLFMNCLYS HFHRHFRIHL
     SATRLVRVST SVASAHTDGK IKILCHKYLI GVLAYMTELA IFQIE