ID   CENPL_XENTR             Reviewed;         348 AA.
AC   Q28HN9;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Centromere protein L;
DE            Short=CENP-L;
GN   Name=cenpl; ORFNames=TTpA009f13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
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DR   EMBL; CR760804; CAJ82931.1; -; mRNA.
DR   RefSeq; NP_001037910.1; NM_001044445.1.
DR   RefSeq; XP_012816691.1; XM_012961237.2.
DR   AlphaFoldDB; Q28HN9; -.
DR   STRING; 8364.ENSXETP00000043247; -.
DR   PaxDb; Q28HN9; -.
DR   GeneID; 733519; -.
DR   KEGG; xtr:733519; -.
DR   CTD; 91687; -.
DR   Xenbase; XB-GENE-5736186; cenpl.
DR   eggNOG; ENOG502QS38; Eukaryota.
DR   InParanoid; Q28HN9; -.
DR   OrthoDB; 1179445at2759; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025204; CENP-L.
DR   PANTHER; PTHR31740; PTHR31740; 1.
DR   Pfam; PF13092; CENP-L; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Centromere protein L"
FT                   /id="PRO_0000249488"
SQ   SEQUENCE   348 AA;  38876 MW;  A99FF6A686C9089A CRC64;
     MQSPTNGVST PKDFSSARRS IQFQNTGFPQ IGLASARRHT PFHHAPSKRR IPQTSPLSET
     VDPLKIALLL SKQWTLYSVT PMHKFSYTNL KEYARLLSAH ICAEKQKGLA VEVGTELNVK
     ATFSPLPGLK GREQDPGSIL IQVLAKPQFS AAGAQDRIVW SGCFCCTFAD EDTLDLLTSE
     TLLCLPLFLV NGAEALTAMV GTWFQKAFDC SFSNLPISSR DLAWMAAMWT GYEAHEHITA
     TEFIFSVPIE PHMDISYAIH PEDIKALWSN IHKGQDEVLA EEVDLLFQCL YTHFFRHFKI
     HLSATHLVKV STSVASAHCD GKVKFLSKEY LLQVLGYLTE LAINNIQY