ID   CENPM_BOVIN             Reviewed;         180 AA.
AC   Q2TBH1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Centromere protein M;
DE            Short=CENP-M;
GN   Name=CENPM;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a
CC       complex that plays a central role in assembly of kinetochore proteins,
CC       mitotic progression and chromosome segregation. The CENPA-NAC complex
CC       recruits the CENPA-CAD (nucleosome distal) complex and may be involved
CC       in incorporation of newly synthesized CENPA into centromeres (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CENPA-NAC complex, at least composed of
CC       CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC
CC       complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK,
CC       CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Nuclear in non-confluent cells and
CC       cytoplasmic in confluent or dividing cells. Localizes in the
CC       kinetochore domain of centromeres (By similarity). {ECO:0000250}.
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DR   EMBL; BC110230; AAI10231.1; -; mRNA.
DR   RefSeq; NP_001033775.1; NM_001038686.2.
DR   AlphaFoldDB; Q2TBH1; -.
DR   SMR; Q2TBH1; -.
DR   STRING; 9913.ENSBTAP00000013133; -.
DR   PaxDb; Q2TBH1; -.
DR   PRIDE; Q2TBH1; -.
DR   Ensembl; ENSBTAT00000013133; ENSBTAP00000013133; ENSBTAG00000009956.
DR   GeneID; 615953; -.
DR   KEGG; bta:615953; -.
DR   CTD; 79019; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009956; -.
DR   VGNC; VGNC:27181; CENPM.
DR   eggNOG; ENOG502S17M; Eukaryota.
DR   GeneTree; ENSGT00390000017504; -.
DR   HOGENOM; CLU_127179_0_0_1; -.
DR   InParanoid; Q2TBH1; -.
DR   OMA; FCELELE; -.
DR   OrthoDB; 1551430at2759; -.
DR   TreeFam; TF328778; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000009956; Expressed in oocyte and 106 other tissues.
DR   ExpressionAtlas; Q2TBH1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR020987; Centromere_Cenp-M.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR34436; PTHR34436; 1.
DR   Pfam; PF11111; CENP-M; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Cytoplasm; Kinetochore; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..180
FT                   /note="Centromere protein M"
FT                   /id="PRO_0000249489"
SQ   SEQUENCE   180 AA;  19635 MW;  22FE3BF69663565C CRC64;
     MSALRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKADC TSELKVHLAR SLPLPCSVNR
     PRIDLIVFVV NLHSKLSLQS VEESLCHLDA AFFLGKVAFL ATGAGRDSHC SIHRNTVVKL
     AHTYRSPLLF CDLEIEDFRA AMAQRLVRLL QICAGHVPGV SALNLLSLMR GSENPSLEDL