ID   CENPM_DANRE             Reviewed;         186 AA.
AC   Q7ZZC6; Q3B7F7;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Centromere protein M;
DE            Short=CENP-M;
DE   AltName: Full=Proliferation-associated nuclear element 1;
GN   Name=cenpm; Synonyms=pane1; ORFNames=zgc:123137;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=15183305; DOI=10.1016/j.modgep.2004.01.008;
RA   Bierie B., Edwin M., Melenhorst J.J., Hennighausen L.;
RT   "The proliferation associated nuclear element (PANE1) is conserved between
RT   mammals and fish and preferentially expressed in activated lymphoid
RT   cells.";
RL   Gene Expr. Patterns 4:389-395(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:15183305}.
CC       Chromosome, centromere {ECO:0000305|PubMed:15183305}. Note=Localizes
CC       exclusively in the centromeres. {ECO:0000305}.
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DR   EMBL; AY277636; AAP33276.1; -; mRNA.
DR   EMBL; BC107627; AAI07628.1; -; mRNA.
DR   RefSeq; NP_991153.2; NM_205590.2.
DR   AlphaFoldDB; Q7ZZC6; -.
DR   SMR; Q7ZZC6; -.
DR   STRING; 7955.ENSDARP00000038262; -.
DR   PaxDb; Q7ZZC6; -.
DR   GeneID; 402852; -.
DR   KEGG; dre:402852; -.
DR   CTD; 402852; -.
DR   ZFIN; ZDB-GENE-040611-4; pane1.
DR   eggNOG; ENOG502S17M; Eukaryota.
DR   InParanoid; Q7ZZC6; -.
DR   OrthoDB; 1551430at2759; -.
DR   PhylomeDB; Q7ZZC6; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q7ZZC6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR020987; Centromere_Cenp-M.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR34436; PTHR34436; 1.
DR   Pfam; PF11111; CENP-M; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Centromere protein M"
FT                   /id="PRO_0000249491"
FT   CONFLICT        118
FT                   /note="S -> N (in Ref. 2; AAI07628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        139
FT                   /note="D -> E (in Ref. 2; AAI07628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        161
FT                   /note="M -> I (in Ref. 2; AAI07628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  20493 MW;  A984CC8BAFEE13A2 CRC64;
     MALLSPYSKV PELNTATVLL VENEEELQNK LANAIVQHEK DFNVNVRLAK KLPLPVENKE
     ARPRIDLIVF IVSLLSERSL QSAESSLSHL HSDCFLGKVC FLVTDARCGS HTQERLVSVR
     KLAASHHCPV ICAEHRTADG VSAAALRLLN ILQVSAGMTP MSTTALYLST LTRCSLTSDL
     QEDYLQ