CENPM_HUMAN
ID CENPM_HUMAN Reviewed; 180 AA.
AC Q9NSP4; A7LM22; B1AHQ9; Q6I9W3;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Centromere protein M;
DE Short=CENP-M;
DE AltName: Full=Interphase centromere complex protein 39;
DE AltName: Full=Proliferation-associated nuclear element protein 1;
GN Name=CENPM; Synonyms=C22orf18, ICEN39, PANE1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16391015; DOI=10.1182/blood-2005-08-3501;
RA Brickner A.G., Evans A.M., Mito J.K., Xuereb S.M., Feng X., Nishida T.,
RA Fairfull L., Ferrell R.E., Foon K.A., Hunt D.F., Shabanowitz J.,
RA Engelhard V.H., Riddell S.R., Warren E.H.;
RT "The PANE1 gene encodes a novel human minor histocompatibility antigen that
RT is selectively expressed in B-lymphoid cells and B-CLL.";
RL Blood 107:3779-3786(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Cervix, Lymph, and Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP SUBCELLULAR LOCATION.
RX PubMed=15183305; DOI=10.1016/j.modgep.2004.01.008;
RA Bierie B., Edwin M., Melenhorst J.J., Hennighausen L.;
RT "The proliferation associated nuclear element (PANE1) is conserved between
RT mammals and fish and preferentially expressed in activated lymphoid
RT cells.";
RL Gene Expr. Patterns 4:389-395(2004).
RN [9]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16716197; DOI=10.1111/j.1365-2443.2006.00969.x;
RA Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y.,
RA Goshima N., Nomura F., Nomura N., Yoda K.;
RT "Comprehensive analysis of the ICEN (Interphase Centromere Complex)
RT components enriched in the CENP-A chromatin of human cells.";
RL Genes Cells 11:673-684(2006).
RN [10]
RP IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPH; CENPN;
RP CENPT AND CENPU.
RX PubMed=16622419; DOI=10.1038/ncb1397;
RA Foltz D.R., Jansen L.E.T., Black B.E., Bailey A.O., Yates J.R. III,
RA Cleveland D.W.;
RT "The human CENP-A centromeric nucleosome-associated complex.";
RL Nat. Cell Biol. 8:458-469(2006).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a
CC complex that plays a central role in assembly of kinetochore proteins,
CC mitotic progression and chromosome segregation. The CENPA-NAC complex
CC recruits the CENPA-CAD (nucleosome distal) complex and may be involved
CC in incorporation of newly synthesized CENPA into centromeres.
CC {ECO:0000269|PubMed:16716197}.
CC -!- SUBUNIT: Component of the CENPA-NAC complex, at least composed of
CC CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC
CC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK,
CC CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.
CC {ECO:0000269|PubMed:16622419}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome, centromere,
CC kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in
CC confluent or dividing cells (By similarity). Localizes in the
CC kinetochore domain of centromeres. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9NSP4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NSP4-2; Sequence=VSP_010259, VSP_010260;
CC Name=3;
CC IsoId=Q9NSP4-3; Sequence=VSP_017726, VSP_017725;
CC Name=4;
CC IsoId=Q9NSP4-4; Sequence=VSP_046189;
CC -!- TISSUE SPECIFICITY: Isoform 3 is highly expressed in spleen, and
CC intermediately in heart, prostate and ovary. Isoform 3 is highly
CC expressed in resting CD19 B-cells and B-lineage chronic lymphocytic
CC leukemia (B-CLL) cells and weakly expressed in activated B-cells.
CC Isoform 1 is selectively expressed in activated CD19 cells and weakly
CC in resting CD19 B-cells.
CC -!- MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.
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DR EMBL; EU035297; ABS84666.1; -; mRNA.
DR EMBL; AL160131; CAB77147.1; -; mRNA.
DR EMBL; AK123479; BAC85624.1; -; mRNA.
DR EMBL; CR456399; CAG30285.1; -; mRNA.
DR EMBL; CR457392; CAG33673.1; -; mRNA.
DR EMBL; Z99716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000705; AAH00705.1; -; mRNA.
DR EMBL; BC007495; AAH07495.1; -; mRNA.
DR EMBL; BU194618; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS14025.1; -. [Q9NSP4-1]
DR CCDS; CCDS46719.1; -. [Q9NSP4-3]
DR CCDS; CCDS46720.1; -. [Q9NSP4-4]
DR RefSeq; NP_001002876.1; NM_001002876.2. [Q9NSP4-4]
DR RefSeq; NP_001103685.1; NM_001110215.2. [Q9NSP4-3]
DR RefSeq; NP_001291299.1; NM_001304370.1.
DR RefSeq; NP_001291300.1; NM_001304371.1. [Q9NSP4-2]
DR RefSeq; NP_001291301.1; NM_001304372.1.
DR RefSeq; NP_001291302.1; NM_001304373.1.
DR RefSeq; NP_076958.1; NM_024053.4. [Q9NSP4-1]
DR PDB; 4P0T; X-ray; 1.49 A; A/B=1-171.
DR PDB; 4WAU; X-ray; 2.20 A; A/B=1-171.
DR PDBsum; 4P0T; -.
DR PDBsum; 4WAU; -.
DR AlphaFoldDB; Q9NSP4; -.
DR SMR; Q9NSP4; -.
DR BioGRID; 122488; 138.
DR ComplexPortal; CPX-5646; Kinetochore CCAN complex.
DR CORUM; Q9NSP4; -.
DR IntAct; Q9NSP4; 11.
DR MINT; Q9NSP4; -.
DR STRING; 9606.ENSP00000215980; -.
DR GlyGen; Q9NSP4; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9NSP4; -.
DR PhosphoSitePlus; Q9NSP4; -.
DR BioMuta; CENPM; -.
DR DMDM; 47117330; -.
DR EPD; Q9NSP4; -.
DR jPOST; Q9NSP4; -.
DR MassIVE; Q9NSP4; -.
DR MaxQB; Q9NSP4; -.
DR PaxDb; Q9NSP4; -.
DR PeptideAtlas; Q9NSP4; -.
DR PRIDE; Q9NSP4; -.
DR ProteomicsDB; 2973; -.
DR ProteomicsDB; 82572; -. [Q9NSP4-1]
DR ProteomicsDB; 82573; -. [Q9NSP4-2]
DR ProteomicsDB; 82574; -. [Q9NSP4-3]
DR Antibodypedia; 27112; 140 antibodies from 25 providers.
DR DNASU; 79019; -.
DR Ensembl; ENST00000215980.10; ENSP00000215980.5; ENSG00000100162.15. [Q9NSP4-1]
DR Ensembl; ENST00000407253.7; ENSP00000384743.3; ENSG00000100162.15. [Q9NSP4-4]
DR Ensembl; ENST00000472374.6; ENSP00000430624.1; ENSG00000100162.15. [Q9NSP4-3]
DR GeneID; 79019; -.
DR KEGG; hsa:79019; -.
DR MANE-Select; ENST00000215980.10; ENSP00000215980.5; NM_024053.5; NP_076958.1.
DR UCSC; uc003bbn.4; human. [Q9NSP4-1]
DR CTD; 79019; -.
DR DisGeNET; 79019; -.
DR GeneCards; CENPM; -.
DR HGNC; HGNC:18352; CENPM.
DR HPA; ENSG00000100162; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 610152; gene.
DR neXtProt; NX_Q9NSP4; -.
DR OpenTargets; ENSG00000100162; -.
DR PharmGKB; PA25885; -.
DR VEuPathDB; HostDB:ENSG00000100162; -.
DR eggNOG; ENOG502S17M; Eukaryota.
DR GeneTree; ENSGT00390000017504; -.
DR HOGENOM; CLU_127179_0_0_1; -.
DR InParanoid; Q9NSP4; -.
DR OMA; FCELELE; -.
DR OrthoDB; 1551430at2759; -.
DR PhylomeDB; Q9NSP4; -.
DR TreeFam; TF328778; -.
DR PathwayCommons; Q9NSP4; -.
DR Reactome; R-HSA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-HSA-2467813; Separation of Sister Chromatids.
DR Reactome; R-HSA-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-HSA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR Reactome; R-HSA-68877; Mitotic Prometaphase.
DR Reactome; R-HSA-9648025; EML4 and NUDC in mitotic spindle formation.
DR SignaLink; Q9NSP4; -.
DR SIGNOR; Q9NSP4; -.
DR BioGRID-ORCS; 79019; 463 hits in 1085 CRISPR screens.
DR ChiTaRS; CENPM; human.
DR GeneWiki; CENPM; -.
DR GenomeRNAi; 79019; -.
DR Pharos; Q9NSP4; Tbio.
DR PRO; PR:Q9NSP4; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9NSP4; protein.
DR Bgee; ENSG00000100162; Expressed in mucosa of transverse colon and 109 other tissues.
DR ExpressionAtlas; Q9NSP4; baseline and differential.
DR Genevisible; Q9NSP4; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR020987; Centromere_Cenp-M.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR34436; PTHR34436; 1.
DR Pfam; PF11111; CENP-M; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Centromere; Chromosome; Cytoplasm;
KW Kinetochore; Nucleus; Reference proteome.
FT CHAIN 1..180
FT /note="Centromere protein M"
FT /id="PRO_0000058224"
FT VAR_SEQ 1..122
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16391015"
FT /id="VSP_017726"
FT VAR_SEQ 104..179
FT /note="AGRESHCSIHRHTVVKLAHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAG
FT HVPGVSALNLLSLLRSSEGPSLED -> GGR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046189"
FT VAR_SEQ 104..132
FT /note="AGRESHCSIHRHTVVKLAHTYQSPLLYCD -> GKYVPRLLLPTPSQGKAGA
FT AVGFLLRHPG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010259"
FT VAR_SEQ 123..134
FT /note="TYQSPLLYCDLE -> MGRVWDLPGVLK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16391015"
FT /id="VSP_017725"
FT VAR_SEQ 133..180
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010260"
FT STRAND 16..21
FT /evidence="ECO:0007829|PDB:4P0T"
FT HELIX 25..36
FT /evidence="ECO:0007829|PDB:4P0T"
FT STRAND 44..53
FT /evidence="ECO:0007829|PDB:4P0T"
FT STRAND 65..71
FT /evidence="ECO:0007829|PDB:4P0T"
FT HELIX 75..85
FT /evidence="ECO:0007829|PDB:4P0T"
FT HELIX 90..93
FT /evidence="ECO:0007829|PDB:4P0T"
FT STRAND 97..103
FT /evidence="ECO:0007829|PDB:4P0T"
FT HELIX 111..123
FT /evidence="ECO:0007829|PDB:4P0T"
FT STRAND 128..130
FT /evidence="ECO:0007829|PDB:4P0T"
FT HELIX 136..153
FT /evidence="ECO:0007829|PDB:4P0T"
FT HELIX 162..165
FT /evidence="ECO:0007829|PDB:4P0T"
SQ SEQUENCE 180 AA; 19737 MW; 37DB044092BF63F4 CRC64;
MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK SLPLPSSVNR
PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL ATGAGRESHC SIHRHTVVKL
AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL QICAGHVPGV SALNLLSLLR SSEGPSLEDL
