CENPN_CHICK
ID CENPN_CHICK Reviewed; 344 AA.
AC Q1T765;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Centromere protein N;
DE Short=CENP-N;
GN Name=CENPN;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16622420; DOI=10.1038/ncb1396;
RA Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA Desai A., Fukagawa T.;
RT "The CENP-H-I complex is required for the efficient incorporation of newly
RT synthesized CENP-A into centromeres.";
RL Nat. Cell Biol. 8:446-457(2006).
CC -!- FUNCTION: Probable component of a centromeric complex involved in
CC assembly of kinetochore proteins, mitotic progression and chromosome
CC segregation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CENP-N/CHL4 family. {ECO:0000305}.
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DR EMBL; AB253769; BAE93421.1; -; mRNA.
DR RefSeq; NP_001038135.1; NM_001044670.1.
DR RefSeq; XP_015148017.1; XM_015292531.1.
DR RefSeq; XP_015148018.1; XM_015292532.1.
DR PDB; 7BXT; EM; 4.20 A; M/N=1-211.
DR PDBsum; 7BXT; -.
DR AlphaFoldDB; Q1T765; -.
DR SMR; Q1T765; -.
DR IntAct; Q1T765; 1.
DR STRING; 9031.ENSGALP00000038350; -.
DR PaxDb; Q1T765; -.
DR Ensembl; ENSGALT00000067512; ENSGALP00000056706; ENSGALG00000013494.
DR Ensembl; ENSGALT00000100967; ENSGALP00000072263; ENSGALG00000013494.
DR GeneID; 693246; -.
DR KEGG; gga:693246; -.
DR CTD; 55839; -.
DR VEuPathDB; HostDB:geneid_693246; -.
DR eggNOG; ENOG502QSE8; Eukaryota.
DR GeneTree; ENSGT00390000004738; -.
DR HOGENOM; CLU_070600_0_0_1; -.
DR InParanoid; Q1T765; -.
DR OrthoDB; 1145159at2759; -.
DR PhylomeDB; Q1T765; -.
DR Reactome; R-GGA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-GGA-9648025; EML4 and NUDC in mitotic spindle formation.
DR PRO; PR:Q1T765; -.
DR Proteomes; UP000000539; Chromosome 11.
DR Bgee; ENSGALG00000013494; Expressed in spermatid and 13 other tissues.
DR ExpressionAtlas; Q1T765; baseline and differential.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR InterPro; IPR007902; Chl4/mis15/CENP-N.
DR Pfam; PF05238; CENP-N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Centromere; Chromosome; Nucleus; Reference proteome.
FT CHAIN 1..344
FT /note="Centromere protein N"
FT /id="PRO_0000249497"
SQ SEQUENCE 344 AA; 40344 MW; EE922893170EDB74 CRC64;
MDEVIVEYIR RTVLKIPRDE IMAVLQKWGF LSEAQLQTIN FRQTKEGISH SVAQLCEESS
ADLKQAALLD IIYNHIYPNK RVWSVYHMNK TGEETDFFDF RDFKKKFRRQ IQSALINVTI
NFREYEDNAI WIRIAWGTPY TKPNQYKTSY VVYHSQTPYV FISASVLRSN LPLLCQAMVV
ASNYHDIHEM ELRSHCLNSL KDIVFKRYSQ NFQTNYPLQE RNVLTENVDL RINDENRSEK
ERIYRLNQES FGNGPQPKLD FAQYKLETMF KSDPKWDVLE KKEPFRCLVK FSSPHLLESL
KSLAPAGLAD APLSPLLTCI PQKARNYFKI REKKSLHPGS FVSP