ID   CENPN_XENTR             Reviewed;         348 AA.
AC   Q5XGF1; Q28E44;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Centromere protein N;
DE            Short=CENP-N;
GN   Name=cenpn; ORFNames=TEgg003d08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-N/CHL4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH84491.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR848458; CAJ82205.1; -; mRNA.
DR   EMBL; BC084491; AAH84491.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001011097.1; NM_001011097.1.
DR   RefSeq; XP_012816431.1; XM_012960977.2.
DR   AlphaFoldDB; Q5XGF1; -.
DR   SMR; Q5XGF1; -.
DR   STRING; 8364.ENSXETP00000000357; -.
DR   PaxDb; Q5XGF1; -.
DR   DNASU; 496510; -.
DR   GeneID; 496510; -.
DR   KEGG; xtr:496510; -.
DR   CTD; 55839; -.
DR   Xenbase; XB-GENE-945688; cenpn.
DR   eggNOG; ENOG502QSE8; Eukaryota.
DR   HOGENOM; CLU_070600_0_0_1; -.
DR   InParanoid; Q5XGF1; -.
DR   OrthoDB; 1145159at2759; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000170; Expressed in egg cell and 10 other tissues.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   InterPro; IPR007902; Chl4/mis15/CENP-N.
DR   Pfam; PF05238; CENP-N; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Nucleus; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Centromere protein N"
FT                   /id="PRO_0000249500"
SQ   SEQUENCE   348 AA;  39701 MW;  B9D904BBA082010E CRC64;
     MDEWIAEFIK RIILKLPFSQ TMTILKAWGF LTDSELQTLT LRYPKDITAT EVVRLCEAKN
     ATIDHAAALD FVFNHAFSNK KLWTVYQMSK TSESENDLFD ASEFKLQFKK SIHAVSKNVT
     INFKEFGEAL WIRIAWGTHN TRPNQYKATF AVYHSQTPHV FITGLGKACR PLLCQALVIA
     SKYSQIQEME LKSRCLESLK DIVFKRFNQP FSSHHSRPHE KALTQKIVDP RVTYENMREK
     ERVHHLTRET FGEGPLPKLE LASYKLETMF RAESIMGGNL TAGNEPFRCV VKFSSPHLLE
     AIRSLAPAGI AEAPISTLLS CIPHKARNSF KITEKRGLHP ASSQPTNF