ID   CENPO_BOVIN             Reviewed;         296 AA.
AC   Q3ZBK8;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Centromere protein O;
DE            Short=CENP-O;
GN   Name=CENPO; Synonyms=MCM21R;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC       complex recruited to centromeres which is involved in assembly of
CC       kinetochore proteins, mitotic progression and chromosome segregation.
CC       May be involved in incorporation of newly synthesized CENPA into
CC       centromeres via its interaction with the CENPA-NAC complex. Modulates
CC       the kinetochore-bound levels of NDC80 complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC       CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC       interacts with the CENPA-NAC complex, at least composed of CENPA,
CC       CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC       Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is
CC       probably recruited on centromeres by the CENPA-NAC complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-O/MCM21 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC103238; AAI03239.1; -; mRNA.
DR   RefSeq; NP_001070471.1; NM_001077003.1.
DR   RefSeq; XP_010808563.1; XM_010810261.2.
DR   RefSeq; XP_010808564.1; XM_010810262.2.
DR   AlphaFoldDB; Q3ZBK8; -.
DR   STRING; 9913.ENSBTAP00000032880; -.
DR   PaxDb; Q3ZBK8; -.
DR   PRIDE; Q3ZBK8; -.
DR   Ensembl; ENSBTAT00000032953; ENSBTAP00000032880; ENSBTAG00000015014.
DR   GeneID; 767930; -.
DR   KEGG; bta:767930; -.
DR   CTD; 79172; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015014; -.
DR   VGNC; VGNC:27183; CENPO.
DR   eggNOG; ENOG502RY72; Eukaryota.
DR   GeneTree; ENSGT00390000016702; -.
DR   HOGENOM; CLU_079531_0_0_1; -.
DR   InParanoid; Q3ZBK8; -.
DR   OMA; FCISTAY; -.
DR   OrthoDB; 954886at2759; -.
DR   TreeFam; TF335524; -.
DR   Reactome; R-BTA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000015014; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0031511; C:Mis6-Sim4 complex; IBA:GO_Central.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0034508; P:centromere complex assembly; IEA:InterPro.
DR   InterPro; IPR018464; CENP-O.
DR   PANTHER; PTHR14582; PTHR14582; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Coiled coil; Kinetochore; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..296
FT                   /note="Centromere protein O"
FT                   /id="PRO_0000249501"
FT   COILED          17..105
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   296 AA;  33893 MW;  65ACD775911394BC CRC64;
     MELANTLRQD GESRGGVLAH LERLETQVSK SRKKLEEPQN AQALEARIHE LKRLRDKLRA
     EVKQRQARVK ASTANVEPDQ ILEISEQEIL ERKQENMKAI LQAYRFTGIS GKLTSRGVCV
     CISTAFEGNL LDSYFVDLVM EKPLWIHHHS VPVFIPLEEI SAKYLQTNTR HFLFVLWEYL
     NAYSGRKYQA DRLQSDFAAF LVGPLQRNSL CNLLSFTYKV KPEGQSFPFC ARLLYKDLTT
     TLPTDVTVTS QGTEALPSTW EEQRAAHENL FFTKPLHQVF TSFAKKGEKL DMSLVS