ID   CENPO_CHICK             Reviewed;         325 AA.
AC   Q1T7B8; Q5ZJK9;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Centromere protein O;
DE            Short=CENP-O;
GN   Name=CENPO; ORFNames=RCJMB04_17f21;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPL; CENPM AND
RP   CENPP.
RX   PubMed=16622420; DOI=10.1038/ncb1396;
RA   Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA   Desai A., Fukagawa T.;
RT   "The CENP-H-I complex is required for the efficient incorporation of newly
RT   synthesized CENP-A into centromeres.";
RL   Nat. Cell Biol. 8:446-457(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [3]
RP   DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, FUNCTION, AND IDENTIFICATION IN
RP   A COMPLEX WITH CENPP; CENPQ; CENPU AND CENPR.
RX   PubMed=18094054; DOI=10.1091/mbc.e07-06-0556;
RA   Hori T., Okada M., Maenaka K., Fukagawa T.;
RT   "CENP-O class proteins form a stable complex and are required for proper
RT   kinetochore function.";
RL   Mol. Biol. Cell 19:843-854(2008).
CC   -!- FUNCTION: Component of the CENPA-HI complex, a centromeric complex
CC       involved in assembly of kinetochore proteins, mitotic progression and
CC       chromosome segregation (By similarity). Involved in kinetochore
CC       assembly and required for recovery from spindle damage. {ECO:0000250,
CC       ECO:0000269|PubMed:18094054}.
CC   -!- SUBUNIT: Component of the CENPA-HI complex, at least composed of CENPH,
CC       CENPI, CENPK, CENPL, CENPM, CENPO and CENPP. Component of a discrete
CC       complex composed of at least CENPO, CENPP, CENPQ, CENPR and CENPU.
CC       {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:18094054}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:18094054}.
CC       Chromosome, centromere {ECO:0000305|PubMed:18094054}. Note=Localizes
CC       exclusively in the centromeres. {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Increases time to progress through G2/M phase.
CC       {ECO:0000269|PubMed:18094054}.
CC   -!- SIMILARITY: Belongs to the CENP-O/MCM21 family. {ECO:0000305}.
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DR   EMBL; AB231850; BAE93415.1; -; mRNA.
DR   EMBL; AJ720425; CAG32084.1; -; mRNA.
DR   RefSeq; NP_001026270.1; NM_001031099.1.
DR   AlphaFoldDB; Q1T7B8; -.
DR   SMR; Q1T7B8; -.
DR   BioGRID; 682757; 2.
DR   STRING; 9031.ENSGALP00000026757; -.
DR   PaxDb; Q1T7B8; -.
DR   GeneID; 422014; -.
DR   KEGG; gga:422014; -.
DR   CTD; 79172; -.
DR   VEuPathDB; HostDB:geneid_422014; -.
DR   eggNOG; ENOG502RY72; Eukaryota.
DR   InParanoid; Q1T7B8; -.
DR   OrthoDB; 954886at2759; -.
DR   PhylomeDB; Q1T7B8; -.
DR   PRO; PR:Q1T7B8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031511; C:Mis6-Sim4 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034508; P:centromere complex assembly; IEA:InterPro.
DR   InterPro; IPR018464; CENP-O.
DR   PANTHER; PTHR14582; PTHR14582; 1.
DR   Pfam; PF09496; CENP-O; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..325
FT                   /note="Centromere protein O"
FT                   /id="PRO_0000249504"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          55..112
FT                   /evidence="ECO:0000255"
FT   CONFLICT        5
FT                   /note="R -> H (in Ref. 1; BAE93415)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8
FT                   /note="D -> N (in Ref. 1; BAE93415)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="R -> Q (in Ref. 1; BAE93415)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        115
FT                   /note="T -> A (in Ref. 1; BAE93415)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        224
FT                   /note="R -> H (in Ref. 1; BAE93415)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  36593 MW;  A69195BA35042650 CRC64;
     MEEERNSDEK ENALCGRSLT AASRDGGGRM PAAPLAQGKV ERGKVYSGDG VLGYLEMLEA
     QAHELGLKQE EKEQQEKKLD RLKARVQELR ARRDELRAKV ELQEKRLLDK EGVMTDPAQP
     SAQTVLEWKV KSLKAMLQVF YLTGISGKLT KQGVCFCIST AYEGTYLDSY YVDLLIKPLV
     KIQRHSVPVF IPLEQIAKKY LQTDIRRFLS VLSDHLNAYV GRRRQADQLE EHFSDHIDGT
     LQRNSLCNLL VFNYTVSSNS KTFPFNVRLL YGDLCCSLPT EAIISCTPGT LPLLAEMAAA
     HSNAFRHMAL HKAFDSLINA KESQN