ID   CENPO_XENTR             Reviewed;         303 AA.
AC   Q28HU3; Q501R3;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Centromere protein O;
DE            Short=CENP-O;
GN   Name=cenpo; ORFNames=TGas100d11.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-O/MCM21 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95911.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR760735; CAJ83414.1; -; mRNA.
DR   EMBL; BC095911; AAH95911.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001037907.2; NM_001044442.3.
DR   RefSeq; NP_001268757.1; NM_001281828.1.
DR   RefSeq; XP_012819499.1; XM_012964045.2.
DR   AlphaFoldDB; Q28HU3; -.
DR   SMR; Q28HU3; -.
DR   STRING; 8364.ENSXETP00000045787; -.
DR   PaxDb; Q28HU3; -.
DR   GeneID; 733516; -.
DR   KEGG; xtr:733516; -.
DR   CTD; 79172; -.
DR   Xenbase; XB-GENE-963144; cenpo.
DR   eggNOG; ENOG502RY72; Eukaryota.
DR   InParanoid; Q28HU3; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031511; C:Mis6-Sim4 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034508; P:centromere complex assembly; IEA:InterPro.
DR   InterPro; IPR018464; CENP-O.
DR   PANTHER; PTHR14582; PTHR14582; 1.
DR   Pfam; PF09496; CENP-O; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Centromere protein O"
FT                   /id="PRO_0000249505"
FT   COILED          38..77
FT                   /evidence="ECO:0000255"
FT   CONFLICT        127
FT                   /note="T -> S (in Ref. 2; AAH95911)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   303 AA;  34192 MW;  99B2CA324284ABD4 CRC64;
     MEQAQSLFRE GVLSHLEQLE ALSYNLAVKQ EKQRQEWAAL RKNQELVLEL RKKRDELKAK
     IERHKAEIQA FRGREEAGED HGSAAGTSQQ AMLELCVEEL KGMLEMHWLT GISGKRTKKG
     VCVCISTAFE GAYLDSFHLD IALKPSVGIS RHSVPPFIPL EQIAKEHLQT DLKKFLSVLF
     EHLNAYAGRK YQFQQLQSFP GGFVRDAQQG NSLHTVLTFG YNVRVEKQPF CLRAKLLYGG
     VTRSLPTEAV ITCEDNRPSV QEKISSHSSL FCQNPLHRAL ECISSEDETL NHSSASLLGT
     HMF