ID   CENPP_DANRE             Reviewed;         282 AA.
AC   Q1LV50; Q6DBW4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Centromere protein P;
DE            Short=CENP-P;
GN   Name=cenpp; ORFNames=zgc:101125;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of a centromeric complex involved in
CC       assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Localizes exclusively in the centromeres.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CENP-P/CTF19 family. {ECO:0000305}.
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DR   EMBL; BX908397; CAK03682.1; -; Genomic_DNA.
DR   EMBL; BX465868; CAK03682.1; JOINED; Genomic_DNA.
DR   EMBL; BX465868; CAK11027.1; -; Genomic_DNA.
DR   EMBL; BX908397; CAK11027.1; JOINED; Genomic_DNA.
DR   EMBL; BC078335; AAH78335.1; -; mRNA.
DR   RefSeq; NP_001003555.1; NM_001003555.2.
DR   AlphaFoldDB; Q1LV50; -.
DR   SMR; Q1LV50; -.
DR   STRING; 7955.ENSDARP00000064804; -.
DR   PaxDb; Q1LV50; -.
DR   PRIDE; Q1LV50; -.
DR   DNASU; 445161; -.
DR   Ensembl; ENSDART00000064805; ENSDARP00000064804; ENSDARG00000044135.
DR   GeneID; 445161; -.
DR   KEGG; dre:445161; -.
DR   CTD; 401541; -.
DR   ZFIN; ZDB-GENE-040801-74; cenpp.
DR   eggNOG; ENOG502S17P; Eukaryota.
DR   GeneTree; ENSGT00390000011897; -.
DR   HOGENOM; CLU_084497_0_0_1; -.
DR   InParanoid; Q1LV50; -.
DR   OMA; TYAEWYE; -.
DR   OrthoDB; 1199362at2759; -.
DR   PhylomeDB; Q1LV50; -.
DR   TreeFam; TF333784; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q1LV50; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000044135; Expressed in mature ovarian follicle and 19 other tissues.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0034080; P:CENP-A containing chromatin assembly; IEA:InterPro.
DR   InterPro; IPR027801; CENP-P.
DR   PANTHER; PTHR28577; PTHR28577; 1.
DR   Pfam; PF13096; CENP-P; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..282
FT                   /note="Centromere protein P"
FT                   /id="PRO_0000249509"
FT   COILED          1..80
FT                   /evidence="ECO:0000255"
FT   CONFLICT        58..59
FT                   /note="AV -> TL (in Ref. 2; AAH78335)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        100
FT                   /note="V -> I (in Ref. 2; AAH78335)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        256
FT                   /note="G -> A (in Ref. 2; AAH78335)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279
FT                   /note="A -> T (in Ref. 2; AAH78335)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   282 AA;  32534 MW;  79062E9D4B9A82C4 CRC64;
     MEQKYEEDIQ KLQQEIEMLE AEQEETLRSI FVQHGDRLQQ GVKSACEERG GGGAQQHAVS
     KLITEVRELE KDLRRQTEIN GITLNECFVK TLHKSERKLV QQLRLAGHCG LLLFQVEFAV
     TEIQEDNVLH RRVTELNIVV DGVEFKDFSA FVSRVEDTKD LLLFFRTLRT FSERCEDRRQ
     TFQHFQEKYP DVVNLPEGCR SEIMIIRSPQ LPGISMTLFW KIHVSKEGVV KPLLDLLLKM
     PDQALELDTK KVMEKGSDYF QSLLQLLGVE ASIEGLIRAV CS