CENPP_MOUSE
ID CENPP_MOUSE Reviewed; 286 AA.
AC Q9CZ92; Q52KM2; Q8C647; Q9CVW9; Q9D5U7;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Centromere protein P;
DE Short=CENP-P;
GN Name=Cenpp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC complex recruited to centromeres which is involved in assembly of
CC kinetochore proteins, mitotic progression and chromosome segregation.
CC May be involved in incorporation of newly synthesized CENPA into
CC centromeres via its interaction with the CENPA-NAC complex (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC interacts with the CENPA-NAC complex, at least composed of CENPA,
CC CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC {ECO:0000250}. Note=Localizes exclusively in the centromeres. The
CC CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC
CC complex (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CZ92-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CZ92-2; Sequence=VSP_020449, VSP_020450;
CC -!- SIMILARITY: Belongs to the CENP-P/CTF19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24472.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB29620.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC36401.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BC094280; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK006234; BAB24472.1; ALT_FRAME; mRNA.
DR EMBL; AK012863; BAB28519.1; -; mRNA.
DR EMBL; AK014919; BAB29620.1; ALT_INIT; mRNA.
DR EMBL; AK076577; BAC36401.1; ALT_FRAME; mRNA.
DR EMBL; BC094280; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS26501.1; -. [Q9CZ92-1]
DR RefSeq; NP_079771.1; NM_025495.3. [Q9CZ92-1]
DR AlphaFoldDB; Q9CZ92; -.
DR SMR; Q9CZ92; -.
DR ComplexPortal; CPX-5704; Kinetochore CCAN complex.
DR CORUM; Q9CZ92; -.
DR IntAct; Q9CZ92; 1.
DR MINT; Q9CZ92; -.
DR STRING; 10090.ENSMUSP00000021818; -.
DR iPTMnet; Q9CZ92; -.
DR PhosphoSitePlus; Q9CZ92; -.
DR EPD; Q9CZ92; -.
DR jPOST; Q9CZ92; -.
DR MaxQB; Q9CZ92; -.
DR PaxDb; Q9CZ92; -.
DR PeptideAtlas; Q9CZ92; -.
DR PRIDE; Q9CZ92; -.
DR ProteomicsDB; 281186; -. [Q9CZ92-1]
DR ProteomicsDB; 281187; -. [Q9CZ92-2]
DR Antibodypedia; 13721; 141 antibodies from 28 providers.
DR DNASU; 66336; -.
DR Ensembl; ENSMUST00000021818; ENSMUSP00000021818; ENSMUSG00000021391. [Q9CZ92-1]
DR GeneID; 66336; -.
DR KEGG; mmu:66336; -.
DR UCSC; uc007qjk.1; mouse. [Q9CZ92-1]
DR UCSC; uc007qjo.1; mouse. [Q9CZ92-2]
DR CTD; 401541; -.
DR MGI; MGI:1913586; Cenpp.
DR VEuPathDB; HostDB:ENSMUSG00000021391; -.
DR eggNOG; ENOG502S17P; Eukaryota.
DR GeneTree; ENSGT00390000011897; -.
DR HOGENOM; CLU_084497_0_0_1; -.
DR InParanoid; Q9CZ92; -.
DR OMA; TYAEWYE; -.
DR PhylomeDB; Q9CZ92; -.
DR TreeFam; TF333784; -.
DR Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-MMU-2467813; Separation of Sister Chromatids.
DR Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
DR Reactome; R-MMU-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR Reactome; R-MMU-68877; Mitotic Prometaphase.
DR Reactome; R-MMU-9648025; EML4 and NUDC in mitotic spindle formation.
DR BioGRID-ORCS; 66336; 22 hits in 74 CRISPR screens.
DR ChiTaRS; Cenpp; mouse.
DR PRO; PR:Q9CZ92; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CZ92; protein.
DR Bgee; ENSMUSG00000021391; Expressed in primitive streak and 157 other tissues.
DR ExpressionAtlas; Q9CZ92; baseline and differential.
DR Genevisible; Q9CZ92; MM.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IEA:InterPro.
DR InterPro; IPR027801; CENP-P.
DR PANTHER; PTHR28577; PTHR28577; 1.
DR Pfam; PF13096; CENP-P; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Centromere; Chromosome; Coiled coil; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..286
FT /note="Centromere protein P"
FT /id="PRO_0000249507"
FT COILED 1..73
FT /evidence="ECO:0000255"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IPU0"
FT VAR_SEQ 188..240
FT /note="EKYPDTVYLLEGTCSHCMEIRSTRQPGFELVIVWKIQIDEEGMVFPKLDLLT
FT K -> THSLSISSQERAGLQETTTKHDQTRNLEAGTYAEAIEGCCLLDWFPWLTQLAL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020449"
FT VAR_SEQ 241..286
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020450"
FT CONFLICT 177
FT /note="E -> G (in Ref. 1; BAC36401)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 286 AA; 33288 MW; 2D58C5766D0B37D6 CRC64;
MDSETRELRA LEAEVAALQR ECRMLQNAGE KASGAWKSFQ KISQSDSEEW ESLKDLRSQL
EHLRSEHSFL SKLTGFNIRN YSKMEDIVNT EETEKDTKKV LQKHRLSGNC NMVTFQLEFE
VLEMETKEKK SSIITDLSII MEPTEYSELS EFASRAEEKR DLLMFFRSLH FFVEWCEYRE
NTFKHFKEKY PDTVYLLEGT CSHCMEIRST RQPGFELVIV WKIQIDEEGM VFPKLDLLTK
VPERALGLDK NRVIETAPLS FRSLLGVLGI EAALDSLIRL FSGDNN
