CENPP_SCHPO
ID CENPP_SCHPO Reviewed; 351 AA.
AC Q9US26;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Inner kinetochore subunit fta2;
DE AltName: Full=CENP-P homolog;
DE AltName: Full=Constitutive centromere-associated network protein fta2;
DE AltName: Full=Sim4 complex subunit fta2;
DE AltName: Full=Sim4-mal2-associated protein 2;
GN Name=fta2; Synonyms=sma2; ORFNames=SPAC1783.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT "Molecular analysis of kinetochore architecture in fission yeast.";
RL EMBO J. 24:2919-2930(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC assembles on centromeric DNA and attaches chromosomes to spindle
CC microtubules, mediating chromosome segregation and sister chromatid
CC segregation during meiosis and mitosis. Component of the inner
CC kinetochore COMA complex, which connects centromere-associated proteins
CC and the outer kinetochore. COMA interacts with other inner kinetochore
CC proteins to form the inner kinetochore constitutive centromere-
CC associated network (CCAN), which serves as a structural platform for
CC outer kinetochore assembly (PubMed:16079914). Fta2, fta3 and fta4
CC associate with the central core (cnt) and inner repeat (inr) region of
CC the centromere (PubMed:16079914). {ECO:0000269|PubMed:16079914}.
CC -!- SUBUNIT: Component of the heterotetrameric kinetochore subcomplex COMA,
CC which consists of fta2, fta7, mal2 and mis17 (By similarity). The COMA
CC subcomplex is part of a larger constitutive centromere-associated
CC network (CCAN) (also known as central kinetochore Sim4 complex in
CC fission yeast), which is composed of at least cnl2, cnp3, cnp20, fta1,
CC fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6, mis15, mis17,
CC sim4 and wip1 (PubMed:16079914). {ECO:0000250|UniProtKB:Q02732,
CC ECO:0000269|PubMed:16079914}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore.
CC -!- SIMILARITY: Belongs to the CENP-P/CTF19 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB66166.1; -; Genomic_DNA.
DR PIR; T50105; T50105.
DR RefSeq; NP_593658.1; NM_001019090.2.
DR AlphaFoldDB; Q9US26; -.
DR SMR; Q9US26; -.
DR BioGRID; 278831; 11.
DR STRING; 4896.SPAC1783.03.1; -.
DR iPTMnet; Q9US26; -.
DR PaxDb; Q9US26; -.
DR PRIDE; Q9US26; -.
DR EnsemblFungi; SPAC1783.03.1; SPAC1783.03.1:pep; SPAC1783.03.
DR GeneID; 2542367; -.
DR KEGG; spo:SPAC1783.03; -.
DR PomBase; SPAC1783.03; fta2.
DR VEuPathDB; FungiDB:SPAC1783.03; -.
DR HOGENOM; CLU_806888_0_0_1; -.
DR OMA; MFGYYHA; -.
DR PRO; PR:Q9US26; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000939; C:inner kinetochore; IDA:PomBase.
DR GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IMP:PomBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IGI:PomBase.
DR InterPro; IPR025213; Sim4_Fta2.
DR Pfam; PF13095; FTA2; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Kinetochore; Microtubule; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..351
FT /note="Inner kinetochore subunit fta2"
FT /id="PRO_0000290638"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 40505 MW; 45017DB34C0EC3B3 CRC64;
MSGRRYSQIS QQEGSSSSDD SDSQQKKTKR TVAHRSPNTT LNGMPRVDSR ARPNENSGQS
KSSNGRVDTD RKMDLLRKRS NLVHQTLLLE KEVRVRRNAI NQRDDSFLSG FIKSLLEIDS
SVVIYNTENP DNPKTKQVMP SAEPKKHVKL NSSISSIRFT QHEFEAESEK IIHHSLKGDI
EYLPSFKFLL EIKVRTIDYA LLFITYKIPH FARKELSSFS DSAIQCLDIV ALLRAFSLFA
HHYSYRCNTW FYLSKHMKKV ASANMDAQCF YVQNSFYKIT ILYEIKFDDL GFVQPNYCIS
YILKNQNEKI VSITSKLLNQ LDKRFSEFVS LFGFREGSLL LLQALFKPHL G
