CENPQ_MACFA
ID CENPQ_MACFA Reviewed; 268 AA.
AC Q4R7G2;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=Centromere protein Q;
DE Short=CENP-Q;
GN Name=CENPQ; ORFNames=QtsA-15415;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC complex recruited to centromeres which is involved in assembly of
CC kinetochore proteins, mitotic progression and chromosome segregation.
CC May be involved in incorporation of newly synthesized CENPA into
CC centromeres via its interaction with the CENPA-NAC complex. Plays an
CC important role in chromosome congression and in the recruitment of
CC CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE
CC and PLK1 to the kinetochores. {ECO:0000250|UniProtKB:Q7L2Z9}.
CC -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC interacts with the CENPA-NAC complex, at least composed of CENPA,
CC CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
CC {ECO:0000250|UniProtKB:Q7L2Z9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7L2Z9}.
CC Chromosome, centromere {ECO:0000250|UniProtKB:Q7L2Z9}. Note=Localizes
CC exclusively in the centromeres. The CENPA-CAD complex is probably
CC recruited on centromeres by the CENPA-NAC complex.
CC {ECO:0000250|UniProtKB:Q7L2Z9}.
CC -!- SIMILARITY: Belongs to the CENP-Q/OKP1 family. {ECO:0000305}.
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DR EMBL; AB168856; BAE00960.1; -; mRNA.
DR RefSeq; NP_001270378.1; NM_001283449.1.
DR AlphaFoldDB; Q4R7G2; -.
DR SMR; Q4R7G2; -.
DR STRING; 9541.XP_005552831.1; -.
DR GeneID; 101867060; -.
DR CTD; 55166; -.
DR eggNOG; ENOG502S34R; Eukaryota.
DR OrthoDB; 1159538at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051310; P:metaphase plate congression; ISS:UniProtKB.
DR GO; GO:1905342; P:positive regulation of protein localization to kinetochore; ISS:UniProtKB.
DR InterPro; IPR025212; CAD_CENP-Q.
DR PANTHER; PTHR31345; PTHR31345; 1.
DR Pfam; PF13094; CENP-Q; 1.
PE 2: Evidence at transcript level;
KW Centromere; Chromosome; Coiled coil; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..268
FT /note="Centromere protein Q"
FT /id="PRO_0000249510"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..203
FT /evidence="ECO:0000255"
FT COMPBIAS 10..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L2Z9"
FT MOD_RES 249
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L2Z9"
SQ SEQUENCE 268 AA; 30980 MW; E8F42B0FC723ED30 CRC64;
MSGKANASKK NFEQLKRNPK RKKDNEEVVL SEKKVRNTVK RNKNHLKDLF SEGQTKHTNL
KQIKIAPNKR KTWQPLSKST RDYLQTMMES VLRTILSDRI KDKEEIQYHL NFLKNRLLQL
CETLKVPPKK MEDLTNVSRL LNMERARGKA NEEGLALLQE EIDKMVETTE LMTGNIQSLK
NKIQILASEV EEEEERVKQI HQINTSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK
DLDILHNSSH MKSMSTFIEE AYKKLNAS