CENPQ_SCHPO
ID CENPQ_SCHPO Reviewed; 244 AA.
AC O74844;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Inner kinetochore subunit fta7;
DE AltName: Full=CENP-Q homolog;
DE AltName: Full=Constitutive centromere-associated network protein fta7;
DE AltName: Full=Sim4 complex subunit fta7;
DE AltName: Full=Sim4-mal2-associated protein 7;
GN Name=fta7; Synonyms=sma7; ORFNames=SPCC1235.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT "Molecular analysis of kinetochore architecture in fission yeast.";
RL EMBO J. 24:2919-2930(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP IDENTIFICATION IN CCAN.
RX PubMed=22561346; DOI=10.1038/ncb2493;
RA Schleiffer A., Maier M., Litos G., Lampert F., Hornung P., Mechtler K.,
RA Westermann S.;
RT "CENP-T proteins are conserved centromere receptors of the Ndc80 complex.";
RL Nat. Cell Biol. 14:604-613(2012).
CC -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC assembles on centromeric DNA and attaches chromosomes to spindle
CC microtubules, mediating chromosome segregation and sister chromatid
CC segregation during meiosis and mitosis. Component of the inner
CC kinetochore COMA complex, which connects centromere-associated proteins
CC and the outer kinetochore. COMA interacts with other inner kinetochore
CC proteins to form the inner kinetochore constitutive centromere-
CC associated network (CCAN), which serves as a structural platform for
CC outer kinetochore assembly. {ECO:0000269|PubMed:16079914}.
CC -!- SUBUNIT: Component of the heterotetrameric kinetochore subcomplex COMA,
CC which consists of fta2, fta7, mal2 and mis17 (By similarity). The COMA
CC subcomplex is part of a larger constitutive centromere-associated
CC network (CCAN) (also known as central kinetochore Sim4 complex in
CC fission yeast), which is composed of at least cnl2, cnp3, cnp20, fta1,
CC fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6, mis15, mis17,
CC sim4 and wip1 (Probable) (PubMed:16079914).
CC {ECO:0000250|UniProtKB:P53298, ECO:0000269|PubMed:16079914,
CC ECO:0000305|PubMed:22561346}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore.
CC Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC body.
CC -!- SIMILARITY: Belongs to the CENP-Q/OKP1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21111.1; -; Genomic_DNA.
DR PIR; T40881; T40881.
DR RefSeq; NP_587733.1; NM_001022728.2.
DR AlphaFoldDB; O74844; -.
DR SMR; O74844; -.
DR BioGRID; 275687; 6.
DR STRING; 4896.SPCC1235.07.1; -.
DR MaxQB; O74844; -.
DR PaxDb; O74844; -.
DR EnsemblFungi; SPCC1235.07.1; SPCC1235.07.1:pep; SPCC1235.07.
DR GeneID; 2539115; -.
DR KEGG; spo:SPCC1235.07; -.
DR PomBase; SPCC1235.07; fta7.
DR VEuPathDB; FungiDB:SPCC1235.07; -.
DR eggNOG; ENOG502SASA; Eukaryota.
DR HOGENOM; CLU_1166427_0_0_1; -.
DR InParanoid; O74844; -.
DR OMA; KRLPRMP; -.
DR PhylomeDB; O74844; -.
DR PRO; PR:O74844; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IC:PomBase.
DR InterPro; IPR025212; CAD_CENP-Q.
DR PANTHER; PTHR31345; PTHR31345; 1.
DR Pfam; PF13094; CENP-Q; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..244
FT /note="Inner kinetochore subunit fta7"
FT /id="PRO_0000290642"
SQ SEQUENCE 244 AA; 28843 MW; B7899EC824E2FAEE CRC64;
MEMKRRVRAV RRDQIQKRWR PLEDKQRQEI IIIFRTCSRL VLNTIKSETR KSLAEEWFMN
ILLKIEAPLR NLPVPRKRKE SILFSQLLSS NMQLEQQLYS DLDHINVLQQ ELKVETARLE
NEQKSYEEMK QNMAINNSRL ADLKSKLHPY LKKGLKISHD NFSDSNDFSF QKKLNTEDSN
TSKTSTLDMY KEKLKPFTKT MQIHANKTVQ LSQTIQKATL LLQRLNNTKN IGLNKSSKLK
IKNI
