ID   CENPR_CHICK             Reviewed;         179 AA.
AC   Q1T763;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Centromere protein R;
DE            Short=CENP-R;
DE   AltName: Full=Nuclear receptor-interacting factor 3;
GN   Name=CENPR; Synonyms=NRIF3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16622420; DOI=10.1038/ncb1396;
RA   Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA   Desai A., Fukagawa T.;
RT   "The CENP-H-I complex is required for the efficient incorporation of newly
RT   synthesized CENP-A into centromeres.";
RL   Nat. Cell Biol. 8:446-457(2006).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21464230; DOI=10.1083/jcb.201012050;
RA   Suzuki A., Hori T., Nishino T., Usukura J., Miyagi A., Morikawa K.,
RA   Fukagawa T.;
RT   "Spindle microtubules generate tension-dependent changes in the
RT   distribution of inner kinetochore proteins.";
RL   J. Cell Biol. 193:125-140(2011).
CC   -!- FUNCTION: Transcription coregulator that can have both coactivator and
CC       corepressor functions. Involved in the coactivation of nuclear
CC       receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-
CC       dependent fashion. Probable component of a centromeric complex involved
CC       in assembly of kinetochore proteins, mitotic progression and chromosome
CC       segregation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21464230}.
CC       Chromosome, centromere {ECO:0000269|PubMed:21464230}. Chromosome,
CC       centromere, kinetochore {ECO:0000269|PubMed:21464230}. Note=Localizes
CC       to the inner kinetochore domain of centromeres.
CC   -!- DOMAIN: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known
CC       to be important for the association with nuclear receptors.
CC       {ECO:0000250}.
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DR   EMBL; AB253771; BAE93423.1; -; mRNA.
DR   AlphaFoldDB; Q1T763; -.
DR   STRING; 9031.ENSGALP00000017885; -.
DR   PaxDb; Q1T763; -.
DR   VEuPathDB; HostDB:geneid_424689; -.
DR   eggNOG; ENOG502S4AR; Eukaryota.
DR   InParanoid; Q1T763; -.
DR   PhylomeDB; Q1T763; -.
DR   PRO; PR:Q1T763; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034080; P:CENP-A containing chromatin assembly; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009601; CENP-R.
DR   PANTHER; PTHR15581; PTHR15581; 1.
DR   Pfam; PF06729; CENP-R; 1.
DR   PIRSF; PIRSF011860; NRIF3_coact_rcpt; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cell cycle; Cell division; Centromere; Chromosome; Kinetochore;
KW   Mitosis; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..179
FT                   /note="Centromere protein R"
FT                   /id="PRO_0000249513"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           172..176
FT                   /note="LXXLL motif"
FT   COMPBIAS        28..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  19562 MW;  CD99EDE17931C029 CRC64;
     MSAKRSLKLD SVKKYNPVEA SPLAKKKDLN SYSPTTGTCQ ISPFSSPTSH NAEDLRNGLS
     HGDETNSESR LSRRGQPQTA EDAFAELQSN VKSSLVRILK ARENLTSLQA LEGSRELENI
     IGVSDSSHIL SAEVQKTQAL MSQAEELQLL KRNHGQLPAR EYAQPASSSA FLQLLLNSL