ID   CENPS_CANAL             Reviewed;         117 AA.
AC   Q5AL63; A0A1D8PFJ2;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Inner kinetochore subunit MHF1;
DE   AltName: Full=CENP-S homolog;
DE   AltName: Full=Constitutive centromere-associated network protein MHF1;
DE   AltName: Full=MHF histone-fold complex subunit 1 {ECO:0000250|UniProtKB:Q3E835};
GN   Name=MHF1 {ECO:0000250|UniProtKB:Q3E835};
GN   OrderedLocusNames=CAALFM_C112840WA; ORFNames=CaO19.12380, CaO19.4914;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: dsDNA-binding component of a FANCM-MHF complex involved in
CC       DNA damage repair and genome maintenance (By similarity). FANCM-MHF
CC       promotes gene conversion at blocked replication forks, probably by
CC       reversal of the stalled fork (By similarity). Component of the
CC       kinetochore, a multiprotein complex that assembles on centromeric DNA
CC       and attaches chromosomes to spindle microtubules, mediating chromosome
CC       segregation and sister chromatid segregation during meiosis and
CC       mitosis. Component of the inner kinetochore constitutive centromere-
CC       associated network (CCAN), which serves as a structural platform for
CC       outer kinetochore assembly (By similarity).
CC       {ECO:0000250|UniProtKB:O74896, ECO:0000250|UniProtKB:Q3E835}.
CC   -!- SUBUNIT: The MHF histone-fold complex is a heterotetramer of 2 MHF1-
CC       MHF2 heterodimers. Together with MPH1/FANCM, forms the FANCM-MHF
CC       complex. Component of the inner kinetochore constitutive centromere-
CC       associated network (CCAN). {ECO:0000250|UniProtKB:Q3E835}.
CC   -!- SIMILARITY: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP017623; AOW26899.1; -; Genomic_DNA.
DR   RefSeq; XP_722125.1; XM_717032.1.
DR   AlphaFoldDB; Q5AL63; -.
DR   SMR; Q5AL63; -.
DR   STRING; 237561.Q5AL63; -.
DR   GeneID; 3636177; -.
DR   KEGG; cal:CAALFM_C112840WA; -.
DR   CGD; CAL0000187076; orf19.12380.
DR   VEuPathDB; FungiDB:C1_12840W_A; -.
DR   eggNOG; ENOG502S7WI; Eukaryota.
DR   HOGENOM; CLU_100369_3_1_1; -.
DR   InParanoid; Q5AL63; -.
DR   OrthoDB; 1483465at2759; -.
DR   PRO; PR:Q5AL63; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0071821; C:FANCM-MHF complex; IBA:GO_Central.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0031297; P:replication fork processing; IBA:GO_Central.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR029003; CENP-S/Mhf1.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF15630; CENP-S; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; DNA-binding; Reference proteome.
FT   CHAIN           1..117
FT                   /note="Inner kinetochore subunit MHF1"
FT                   /id="PRO_0000424606"
SQ   SEQUENCE   117 AA;  13282 MW;  4CBA0EFAD6AF9A51 CRC64;
     MVKQQSKEEI ALQLKSAVYL SVAKIVEAKL EDLNNDNAAT TTTESNNKNN NNNMLIATPT
     FIAQLVELVY NQLINLGEDL ELFCQHANRD IVEPSDLFMV TRKNPTLQQH LKDLLRQ