CENPU_CHICK
ID CENPU_CHICK Reviewed; 345 AA.
AC Q2Z1W2;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Centromere protein U;
DE Short=CENP-U;
DE AltName: Full=Centromere protein p50;
DE AltName: Full=MLF1-interacting protein;
DE AltName: Full=centromere protein of 50 kDa;
DE Short=CENP-50;
GN Name=CENPU; Synonyms=CENP50, MLF1IP;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
RP WITH CENPH-CENPI COMPLEX.
RX PubMed=16287847; DOI=10.1128/mcb.25.23.10315-10328.2005;
RA Minoshima Y., Hori T., Okada M., Kimura H., Haraguchi T., Hiraoka Y.,
RA Bao Y.-C., Kawashima T., Kitamura T., Fukagawa T.;
RT "The constitutive centromere component CENP-50 is required for recovery
RT from spindle damage.";
RL Mol. Cell. Biol. 25:10315-10328(2005).
CC -!- FUNCTION: Probable component of a centromeric complex involved in
CC assembly of kinetochore proteins, mitotic progression and chromosome
CC segregation. Required for maintenance of sister chromatid adhesion
CC during mitotic checkpoint activation. {ECO:0000269|PubMed:16287847}.
CC -!- SUBUNIT: Interacts with CENPH-CENPI complex at the kinetochore.
CC {ECO:0000269|PubMed:16287847}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16287847}.
CC Chromosome, centromere {ECO:0000269|PubMed:16287847}. Note=Localizes to
CC the centromeres throughout the cell cycle.
CC -!- SIMILARITY: Belongs to the CENP-U/AME1 family. {ECO:0000305}.
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DR EMBL; AB233421; BAE48587.1; -; mRNA.
DR RefSeq; NP_001034388.1; NM_001039299.1.
DR AlphaFoldDB; Q2Z1W2; -.
DR SMR; Q2Z1W2; -.
DR STRING; 9031.ENSGALP00000031579; -.
DR PaxDb; Q2Z1W2; -.
DR GeneID; 422548; -.
DR KEGG; gga:422548; -.
DR CTD; 79682; -.
DR VEuPathDB; HostDB:geneid_422548; -.
DR eggNOG; ENOG502S1IM; Eukaryota.
DR InParanoid; Q2Z1W2; -.
DR OrthoDB; 970617at2759; -.
DR PhylomeDB; Q2Z1W2; -.
DR PRO; PR:Q2Z1W2; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR025214; CENP-U.
DR Pfam; PF13097; CENP-U; 1.
PE 1: Evidence at protein level;
KW Centromere; Chromosome; Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..345
FT /note="Centromere protein U"
FT /id="PRO_0000247675"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..294
FT /evidence="ECO:0000255"
FT MOTIF 222..239
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 7..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 39638 MW; 81721A4A82E30ABF CRC64;
MSSKKRTKRN RAGDEYKEHK GRSHPRRKFL PPEEPDVSRI SKVAGVNQLE ELCDSFDQPL
HSTAVDACGE EHSENESSGY VPAPQRTNAE RSEKMLLETP EGDVHEFSQS GSVREPLMEN
LNAPNTTRSE VKKKRPSKKS SSDSSVNSPS SVQLWCPNKL KRSSRDITEL DVVLAEFEKI
AANYRQSIES KACRKAVSAF CSAFEDQVTD LITEVQELKN TKKKNAKVVA DIKKKRQRLM
QVREKLSRTE PQLIKLQKEY AEVEERRSSL RQVVQFLTDL KELQQDYLDY REENPRKKVV
YGASSLPALL VESRRILQAE RHFQNINRKL EYALEVQRGK LAKEH
