ID   CENPU_SCHPO             Reviewed;         441 AA.
AC   O94643;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Inner kinetochore subunit mis17;
DE   AltName: Full=CENP-U homolog;
DE   AltName: Full=Constitutive centromere-associated network protein mis17;
DE   AltName: Full=Sim4 complex subunit mis17;
GN   Name=mis17; ORFNames=SPBC21.01, SPBC776.19;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, INTERACTION WITH MIS6 AND MIS15, AND SUBCELLULAR LOCATION.
RX   PubMed=15369671; DOI=10.1016/j.cell.2004.09.002;
RA   Hayashi T., Fujita Y., Iwasaki O., Adachi Y., Takahashi K., Yanagida M.;
RT   "Mis16 and Mis18 are required for CENP-A loading and histone deacetylation
RT   at centromeres.";
RL   Cell 118:715-729(2004).
RN   [3]
RP   FUNCTION, AND IDENTIFICATION IN THE SIM4 COMPLEX.
RX   PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA   Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT   "Molecular analysis of kinetochore architecture in fission yeast.";
RL   EMBO J. 24:2919-2930(2005).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC       assembles on centromeric DNA and attaches chromosomes to spindle
CC       microtubules, mediating chromosome segregation and sister chromatid
CC       segregation during meiosis and mitosis. Component of the inner
CC       kinetochore COMA complex, which connects centromere-associated proteins
CC       and the outer kinetochore. COMA interacts with other inner kinetochore
CC       proteins to form the inner kinetochore constitutive centromere-
CC       associated network (CCAN), which serves as a structural platform for
CC       outer kinetochore assembly. {ECO:0000269|PubMed:15369671,
CC       ECO:0000269|PubMed:16079914}.
CC   -!- SUBUNIT: Component of the heterotetrameric kinetochore subcomplex COMA,
CC       which consists of fta2, fta7, mal2 and mis17 (By similarity). The COMA
CC       subcomplex is part of a larger constitutive centromere-associated
CC       network (CCAN) (also known as central kinetochore Sim4 complex in
CC       fission yeast), which is composed of at least cnl2, cnp3, cnp20, fta1,
CC       fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6, mis15, mis17,
CC       sim4 and wip1 (PubMed:15369671, PubMed:16079914). Interacts with mis6
CC       and mis15 (PubMed:15369671). {ECO:0000250|UniProtKB:P38313,
CC       ECO:0000269|PubMed:15369671, ECO:0000269|PubMed:16079914}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome,
CC       centromere, kinetochore.
CC   -!- SIMILARITY: Belongs to the CENP-U/AME1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329671; CAD56489.1; -; Genomic_DNA.
DR   PIR; T39883; T39883.
DR   RefSeq; NP_001018835.1; NM_001022256.2.
DR   AlphaFoldDB; O94643; -.
DR   SMR; O94643; -.
DR   BioGRID; 280403; 33.
DR   IntAct; O94643; 2.
DR   STRING; 4896.SPBC21.01.1; -.
DR   iPTMnet; O94643; -.
DR   MaxQB; O94643; -.
DR   PaxDb; O94643; -.
DR   PRIDE; O94643; -.
DR   EnsemblFungi; SPBC21.01.1; SPBC21.01.1:pep; SPBC21.01.
DR   GeneID; 3361327; -.
DR   KEGG; spo:SPBC21.01; -.
DR   PomBase; SPBC21.01; mis17.
DR   VEuPathDB; FungiDB:SPBC21.01; -.
DR   eggNOG; ENOG502R7H1; Eukaryota.
DR   HOGENOM; CLU_621357_0_0_1; -.
DR   OMA; VEFSIDP; -.
DR   PRO; PR:O94643; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR   GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034080; P:CENP-A containing chromatin assembly; IMP:PomBase.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Kinetochore; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..441
FT                   /note="Inner kinetochore subunit mis17"
FT                   /id="PRO_0000116523"
FT   REGION          160..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  49666 MW;  A65FD10DC3DA4C98 CRC64;
     MENNSHNVDE RRAARMRGAE RYKIQNVEFS LDQNLLANLE SSTSSSTRSS PASNQQNLEI
     VSQSEAYHKI SDLDDSTSIF SISDQENILE RRISEEVVRE NSVSSIENVS SSAVARETQS
     SANILVKDNH FFSHKQKKIQ RESIPFHKRD NIETSDAYSS SILENSPPNK VQRLSSLDSS
     QDSFQEEHPG NVTGTTFSSQ APEERIASPI STSSPESLTN QSSSLQSSLQ TSSMAPRNLL
     DQSTEKDIVV GASDELVRIE LTKLSKEAGG SKTLNELDAV QQFFQEFIKE NEPLEPYVVK
     VKNAFVEQVS IRLLELIDLL DANRILSTAC KKAANEKLAV QRDLSKLRED RLSVQRKKIQ
     LRNEYIKLSH QQNFLDDIDD FFSQCETVKN ELENVTTTPN STEAFSEINE YASALSKNYG
     LESQLVELQS LLTQFYQKFL S