CENPW_MOUSE
ID CENPW_MOUSE Reviewed; 86 AA.
AC Q3URR0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Centromere protein W;
DE Short=CENP-W;
DE AltName: Full=Cancer-up-regulated gene 2 protein;
GN Name=Cenpw; Synonyms=Cug2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION.
RX PubMed=17610844; DOI=10.1016/j.bbrc.2007.06.102;
RA Lee S., Gang J., Jeon S.B., Choo S.H., Lee B., Kim Y.-G., Lee Y.S.,
RA Jung J., Song S.Y., Koh S.S.;
RT "Molecular cloning and functional analysis of a novel oncogene, cancer-
RT upregulated gene 2 (CUG2).";
RL Biochem. Biophys. Res. Commun. 360:633-639(2007).
CC -!- FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a
CC complex that plays a central role in assembly of kinetochore proteins,
CC mitotic progression and chromosome segregation (By similarity). The
CC CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex
CC and may be involved in incorporation of newly synthesized CENPA into
CC centromeres (By similarity). Part of a nucleosome-associated complex
CC that binds specifically to histone H3-containing nucleosomes at the
CC centromere, as opposed to nucleosomes containing CENPA. Component of
CC the heterotetrameric CENP-T-W-S-X complex that binds and supercoils
CC DNA, and plays an important role in kinetochore assembly. CENPW has a
CC fundamental role in kinetochore assembly and function. It is one of the
CC inner kinetochore proteins, with most further proteins binding
CC downstream. Required for normal chromosome organization and normal
CC progress through mitosis (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:17610844}.
CC -!- SUBUNIT: Heterodimer with CENPT; this dimer coassembles with CENPS-
CC CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X
CC complex, which is a subcomplex of the large constitutive centromere-
CC associated network (CCAN, also known as the interphase centromere
CC complex or ICEN). Interacts with NPM1. {ECO:0000250|UniProtKB:Q5EE01}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5EE01}.
CC Chromosome, centromere {ECO:0000250|UniProtKB:Q5EE01}. Chromosome,
CC centromere, kinetochore {ECO:0000250|UniProtKB:Q5EE01}. Nucleus matrix
CC {ECO:0000250|UniProtKB:Q5EE01}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q5EE01}. Note=Constitutively localizes to
CC centromeres throughout the cell cycle, and to the inner kinetochore
CC during mitosis. {ECO:0000250|UniProtKB:P0DJH6}.
CC -!- SIMILARITY: Belongs to the CENP-W/WIP1 family. {ECO:0000305}.
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DR EMBL; AK141272; BAE24628.1; -; mRNA.
DR CCDS; CCDS35876.1; -.
DR RefSeq; NP_001103217.1; NM_001109747.1.
DR AlphaFoldDB; Q3URR0; -.
DR SMR; Q3URR0; -.
DR ComplexPortal; CPX-5704; Kinetochore CCAN complex.
DR STRING; 10090.ENSMUSP00000097565; -.
DR PhosphoSitePlus; Q3URR0; -.
DR MaxQB; Q3URR0; -.
DR PaxDb; Q3URR0; -.
DR PRIDE; Q3URR0; -.
DR Antibodypedia; 32744; 70 antibodies from 23 providers.
DR Ensembl; ENSMUST00000099985; ENSMUSP00000097565; ENSMUSG00000075266.
DR GeneID; 66311; -.
DR KEGG; mmu:66311; -.
DR UCSC; uc007etc.3; mouse.
DR CTD; 387103; -.
DR MGI; MGI:1913561; Cenpw.
DR VEuPathDB; HostDB:ENSMUSG00000075266; -.
DR eggNOG; ENOG502SGDW; Eukaryota.
DR GeneTree; ENSGT00390000010369; -.
DR HOGENOM; CLU_178644_1_0_1; -.
DR InParanoid; Q3URR0; -.
DR OMA; IIKKDHV; -.
DR OrthoDB; 1578618at2759; -.
DR PhylomeDB; Q3URR0; -.
DR TreeFam; TF343285; -.
DR Reactome; R-MMU-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR BioGRID-ORCS; 66311; 25 hits in 72 CRISPR screens.
DR ChiTaRS; Cenpw; mouse.
DR PRO; PR:Q3URR0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q3URR0; protein.
DR Bgee; ENSMUSG00000075266; Expressed in yolk sac and 176 other tissues.
DR ExpressionAtlas; Q3URR0; baseline and differential.
DR Genevisible; Q3URR0; MM.
DR GO; GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051276; P:chromosome organization; ISS:UniProtKB.
DR GO; GO:0007059; P:chromosome segregation; ISS:UniProtKB.
DR GO; GO:0051382; P:kinetochore assembly; ISS:UniProtKB.
DR GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR028847; CENP-W.
DR InterPro; IPR009072; Histone-fold.
DR Pfam; PF15510; CENP-W; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; DNA-binding;
KW Kinetochore; Mitosis; Nucleus; Reference proteome; Tumor suppressor.
FT CHAIN 1..86
FT /note="Centromere protein W"
FT /id="PRO_0000311184"
SQ SEQUENCE 86 AA; 9734 MW; 1BEB2BD950E5DE96 CRC64;
MAPSTTVTRR VKRKAPRAFL KRTLKQKKPH LGLGRCCDLL IHLNCLLFIQ RLAEESRTNA
CESKSRVIKK DHVLAAGKVI LKKSRG
