ID   CENPW_RAT               Reviewed;          86 AA.
AC   A1L1L1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Centromere protein W;
DE            Short=CENP-W;
DE   AltName: Full=Cancer-up-regulated gene 2 protein;
GN   Name=Cenpw; Synonyms=Cug2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a
CC       complex that plays a central role in assembly of kinetochore proteins,
CC       mitotic progression and chromosome segregation (By similarity). The
CC       CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex
CC       and may be involved in incorporation of newly synthesized CENPA into
CC       centromeres (By similarity). Part of a nucleosome-associated complex
CC       that binds specifically to histone H3-containing nucleosomes at the
CC       centromere, as opposed to nucleosomes containing CENPA. Component of
CC       the heterotetrameric CENP-T-W-S-X complex that binds and supercoils
CC       DNA, and plays an important role in kinetochore assembly. CENPW has a
CC       fundamental role in kinetochore assembly and function. It is one of the
CC       inner kinetochore proteins, with most further proteins binding
CC       downstream. Required for normal chromosome organization and normal
CC       progress through mitosis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with CENPT; this dimer coassembles with CENPS-
CC       CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X
CC       complex, which is a subcomplex of the large constitutive centromere-
CC       associated network (CCAN, also known as the interphase centromere
CC       complex or ICEN). Interacts with NPM1. {ECO:0000250|UniProtKB:Q5EE01}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5EE01}.
CC       Chromosome, centromere {ECO:0000250|UniProtKB:Q5EE01}. Chromosome,
CC       centromere, kinetochore {ECO:0000250|UniProtKB:Q5EE01}. Nucleus matrix
CC       {ECO:0000250|UniProtKB:Q5EE01}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q5EE01}. Note=Constitutively localizes to
CC       centromeres throughout the cell cycle, and to the inner kinetochore
CC       during mitosis. {ECO:0000250|UniProtKB:P0DJH6}.
CC   -!- SIMILARITY: Belongs to the CENP-W/WIP1 family. {ECO:0000305}.
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DR   EMBL; BC129114; AAI29115.1; -; mRNA.
DR   RefSeq; NP_001233248.1; NM_001246319.1.
DR   AlphaFoldDB; A1L1L1; -.
DR   SMR; A1L1L1; -.
DR   STRING; 10116.ENSRNOP00000061737; -.
DR   PaxDb; A1L1L1; -.
DR   Ensembl; ENSRNOT00000065677; ENSRNOP00000061737; ENSRNOG00000042944.
DR   GeneID; 689399; -.
DR   KEGG; rno:689399; -.
DR   UCSC; RGD:1593465; rat.
DR   CTD; 387103; -.
DR   RGD; 1593465; Cenpw.
DR   eggNOG; ENOG502SGDW; Eukaryota.
DR   GeneTree; ENSGT00390000010369; -.
DR   HOGENOM; CLU_178644_1_0_1; -.
DR   InParanoid; A1L1L1; -.
DR   OMA; IIKKDHV; -.
DR   OrthoDB; 1578618at2759; -.
DR   PhylomeDB; A1L1L1; -.
DR   TreeFam; TF343285; -.
DR   Reactome; R-RNO-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   PRO; PR:A1L1L1; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000042944; Expressed in thymus and 15 other tissues.
DR   Genevisible; A1L1L1; RN.
DR   GO; GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051276; P:chromosome organization; ISS:UniProtKB.
DR   GO; GO:0007059; P:chromosome segregation; ISS:UniProtKB.
DR   GO; GO:0051382; P:kinetochore assembly; ISS:UniProtKB.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR028847; CENP-W.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF15510; CENP-W; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; DNA-binding;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome; Tumor suppressor.
FT   CHAIN           1..86
FT                   /note="Centromere protein W"
FT                   /id="PRO_0000311185"
SQ   SEQUENCE   86 AA;  9803 MW;  44B07EA42162C201 CRC64;
     MVLSTTVCRR IRRKAPCAFL KRTLKQKKPR LSLEKRCDLL IHLNCLLFVQ KLAEESRTNA
     CESKSGVIKK DHVQAAAKVI LKKSRG