ID   CENPX_ARATH             Reviewed;         104 AA.
AC   Q8L7N3; Q9ZV97;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Protein MHF2 homolog {ECO:0000303|PubMed:25038251};
DE            Short=AtMHF2 {ECO:0000303|PubMed:25038251};
GN   Name=MHF2 {ECO:0000303|PubMed:25038251};
GN   OrderedLocusNames=At1g78790 {ECO:0000312|Araport:AT1G78790};
GN   ORFNames=F9K20.17 {ECO:0000312|EMBL:AEE36153.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION.
RX   PubMed=25038251; DOI=10.1093/nar/gku614;
RA   Girard C., Crismani W., Froger N., Mazel J., Lemhemdi A., Horlow C.,
RA   Mercier R.;
RT   "FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia
RT   factors, limit meiotic crossovers.";
RL   Nucleic Acids Res. 42:9087-9095(2014).
CC   -!- FUNCTION: Acts in the same pathway as FANCM to restrain class II
CC       meiotic crossing over (CO), and acts with FANCM during meiosis to
CC       repair interstrand cross-links (ICLs). {ECO:0000269|PubMed:25038251}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25038251}.
CC   -!- SIMILARITY: Belongs to the CENP-X/MHF2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC83046.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC005679; AAC83046.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE36153.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM60849.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM60850.1; -; Genomic_DNA.
DR   EMBL; AY128353; AAM91556.1; -; mRNA.
DR   EMBL; BT001158; AAN65045.1; -; mRNA.
DR   PIR; A96817; A96817.
DR   RefSeq; NP_001323102.1; NM_001334847.1.
DR   RefSeq; NP_001323103.1; NM_001334846.1.
DR   RefSeq; NP_178000.2; NM_106526.4.
DR   AlphaFoldDB; Q8L7N3; -.
DR   SMR; Q8L7N3; -.
DR   STRING; 3702.AT1G78790.1; -.
DR   PaxDb; Q8L7N3; -.
DR   ProteomicsDB; 220542; -.
DR   EnsemblPlants; AT1G78790.1; AT1G78790.1; AT1G78790.
DR   EnsemblPlants; AT1G78790.3; AT1G78790.3; AT1G78790.
DR   EnsemblPlants; AT1G78790.4; AT1G78790.4; AT1G78790.
DR   GeneID; 844215; -.
DR   Gramene; AT1G78790.1; AT1G78790.1; AT1G78790.
DR   Gramene; AT1G78790.3; AT1G78790.3; AT1G78790.
DR   Gramene; AT1G78790.4; AT1G78790.4; AT1G78790.
DR   KEGG; ath:AT1G78790; -.
DR   Araport; AT1G78790; -.
DR   TAIR; locus:2037488; AT1G78790.
DR   eggNOG; ENOG502S5FD; Eukaryota.
DR   HOGENOM; CLU_154199_1_0_1; -.
DR   InParanoid; Q8L7N3; -.
DR   OMA; FRRAQME; -.
DR   OrthoDB; 1568573at2759; -.
DR   PhylomeDB; Q8L7N3; -.
DR   PRO; PR:Q8L7N3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8L7N3; baseline and differential.
DR   GO; GO:0071821; C:FANCM-MHF complex; IBA:GO_Central.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IGI:TAIR.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR   GO; GO:0031297; P:replication fork processing; IBA:GO_Central.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR   InterPro; IPR018552; CENP-X.
DR   PANTHER; PTHR28680; PTHR28680; 1.
DR   Pfam; PF09415; CENP-X; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..104
FT                   /note="Protein MHF2 homolog"
FT                   /id="PRO_0000440039"
SQ   SEQUENCE   104 AA;  11681 MW;  218C6123164EEEA8 CRC64;
     MDANNTFDSD LIHAIFKHIW ARRFRERERS DAIDATEAEV ALGTTKKNRL ASANANALKL
     SCELLKSFVS EAVQRAAIIA EAEGMEKIEA THLERILPQL LLDF