ID   CEP19_DANRE             Reviewed;         161 AA.
AC   Q4V8Z3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Centrosomal protein of 19 kDa;
DE            Short=Cep19;
GN   Name=cep19; ORFNames=si:ch73-159l23.3, zgc:114076;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliation. Recruits the RABL2B GTPase to the
CC       ciliary base to initiate ciliation. {ECO:0000250|UniProtKB:Q96LK0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:Q96LK0}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96LK0}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q96LK0}. Note=Associates with the mother
CC       centriole in early interphase. Localizes to spindle poles during
CC       mitosis, and to distinct foci oriented towards the midbody at
CC       telophase. Localizes slightly apical to the subdistal appendage on the
CC       mother centriole, but below the distal appendage.
CC       {ECO:0000250|UniProtKB:Q96LK0}.
CC   -!- SIMILARITY: Belongs to the CEP19 family. {ECO:0000305}.
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DR   EMBL; CT027565; CAN87995.1; -; Genomic_DNA.
DR   EMBL; BC097138; AAH97138.1; -; mRNA.
DR   RefSeq; NP_001028906.1; NM_001033734.1.
DR   AlphaFoldDB; Q4V8Z3; -.
DR   STRING; 7955.ENSDARP00000122139; -.
DR   PaxDb; Q4V8Z3; -.
DR   Ensembl; ENSDART00000082222; ENSDARP00000076659; ENSDARG00000059175.
DR   Ensembl; ENSDART00000135507; ENSDARP00000122139; ENSDARG00000059175.
DR   Ensembl; ENSDART00000143258; ENSDARP00000117048; ENSDARG00000059175.
DR   GeneID; 619252; -.
DR   KEGG; dre:619252; -.
DR   CTD; 84984; -.
DR   ZFIN; ZDB-GENE-050913-81; cep19.
DR   eggNOG; ENOG502RZP1; Eukaryota.
DR   GeneTree; ENSGT00390000016356; -.
DR   HOGENOM; CLU_113348_0_0_1; -.
DR   InParanoid; Q4V8Z3; -.
DR   OMA; QEKCSWD; -.
DR   OrthoDB; 1594443at2759; -.
DR   PhylomeDB; Q4V8Z3; -.
DR   TreeFam; TF328425; -.
DR   PRO; PR:Q4V8Z3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000059175; Expressed in testis and 20 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0034454; P:microtubule anchoring at centrosome; IBA:GO_Central.
DR   GO; GO:0097712; P:vesicle targeting, trans-Golgi to periciliary membrane compartment; IBA:GO_Central.
DR   InterPro; IPR029412; CEP19.
DR   PANTHER; PTHR31539; PTHR31539; 2.
DR   Pfam; PF14933; CEP19; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..161
FT                   /note="Centrosomal protein of 19 kDa"
FT                   /id="PRO_0000360404"
FT   REGION          89..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   161 AA;  18905 MW;  9E11272D0D6B027A CRC64;
     MSIVAKRCGV KFTPPSIIII YENKTSGKMR KRVIPVRNFS QYSDCSRAAE RLKHHVRHSV
     YLECVSLAQL ERLHLLLRDH LQGASLEESL AAHRHQEEEE DLNKLSDEEL SRRKAQMDDL
     FQRNRRRRGD PDFVYDLEVE FGEGSVKETC SWDEEQSDQE F