ID   CEP19_XENTR             Reviewed;         163 AA.
AC   A9UL78;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Centrosomal protein of 19 kDa;
DE            Short=Cep19;
GN   Name=cep19;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliation. Recruits the RABL2B GTPase to the
CC       ciliary base to initiate ciliation. {ECO:0000250|UniProtKB:Q96LK0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:Q96LK0}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96LK0}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q96LK0}. Note=Associates with the mother
CC       centriole in early interphase. Localizes to spindle poles during
CC       mitosis, and to distinct foci oriented towards the midbody at
CC       telophase. Localizes slightly apical to the subdistal appendage on the
CC       mother centriole, but below the distal appendage.
CC       {ECO:0000250|UniProtKB:Q96LK0}.
CC   -!- SIMILARITY: Belongs to the CEP19 family. {ECO:0000305}.
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DR   EMBL; BC157153; AAI57154.1; -; mRNA.
DR   RefSeq; NP_001107342.1; NM_001113870.1.
DR   AlphaFoldDB; A9UL78; -.
DR   STRING; 8364.ENSXETP00000036562; -.
DR   PaxDb; A9UL78; -.
DR   Ensembl; ENSXETT00000036562; ENSXETP00000036562; ENSXETG00000016761.
DR   GeneID; 100135164; -.
DR   KEGG; xtr:100135164; -.
DR   CTD; 84984; -.
DR   Xenbase; XB-GENE-1003989; cep19.
DR   eggNOG; ENOG502RZP1; Eukaryota.
DR   HOGENOM; CLU_113348_0_0_1; -.
DR   InParanoid; A9UL78; -.
DR   OMA; QEKCSWD; -.
DR   OrthoDB; 1594443at2759; -.
DR   PhylomeDB; A9UL78; -.
DR   TreeFam; TF328425; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016761; Expressed in gastrula and 7 other tissues.
DR   ExpressionAtlas; A9UL78; baseline and differential.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0034454; P:microtubule anchoring at centrosome; IBA:GO_Central.
DR   GO; GO:0097712; P:vesicle targeting, trans-Golgi to periciliary membrane compartment; IBA:GO_Central.
DR   InterPro; IPR029412; CEP19.
DR   PANTHER; PTHR31539; PTHR31539; 2.
DR   Pfam; PF14933; CEP19; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..163
FT                   /note="Centrosomal protein of 19 kDa"
FT                   /id="PRO_0000360406"
SQ   SEQUENCE   163 AA;  19194 MW;  E7E765D6FA190702 CRC64;
     MSYMAKKCGV RFQPPAIILV YEDKEAGKSR QRIMPIRNFS KYSDCSRAAE QLKNNPRHKD
     YLDLVSLRQL EKLYKLLKGH LKGESLKVTL EEIKKEETID PEEDLNKLDD KELAKRKHVM
     DELFEKNRKK KDDPDFEYEI EVDFTKDEQA ESCGWDDASD EGF