ID   CEP1_HCMVA              Reviewed;         249 AA.
AC   P16734; Q7M6T6;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cytoplasmic envelopment protein 1 {ECO:0000255|HAMAP-Rule:MF_04038};
GN   Name=UL103;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [5]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
RN   [6]
RP   FUNCTION.
RX   PubMed=24899189; DOI=10.1128/jvi.01141-14;
RA   Das S., Ortiz D.A., Gurczynski S.J., Khan F., Pellett P.E.;
RT   "Identification of human cytomegalovirus genes important for biogenesis of
RT   the cytoplasmic virion assembly complex.";
RL   J. Virol. 88:9086-9099(2014).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_04038, ECO:0000269|PubMed:24899189}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04038,
CC       ECO:0000269|PubMed:15452216}. Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04038, ECO:0000269|PubMed:15452216}. Host cytoplasm
CC       {ECO:0000255|HAMAP-Rule:MF_04038}. Host Golgi apparatus
CC       {ECO:0000255|HAMAP-Rule:MF_04038}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 1 family. {ECO:0000255|HAMAP-Rule:MF_04038}.
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DR   EMBL; X17403; CAA35339.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00098.1; -; Genomic_DNA.
DR   PIR; S09868; S09868.
DR   RefSeq; YP_081549.1; NC_006273.2.
DR   PRIDE; P16734; -.
DR   GeneID; 3077559; -.
DR   KEGG; vg:3077559; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04038; HSV_CEP1; 1.
DR   InterPro; IPR002600; Herpes_UL7.
DR   Pfam; PF01677; Herpes_UL7; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..249
FT                   /note="Cytoplasmic envelopment protein 1"
FT                   /id="PRO_0000115924"
SQ   SEQUENCE   249 AA;  28636 MW;  A8D9F8F89F02FE9D CRC64;
     MEALMIRGVL EVHTDFTRQN VMIMEPQVLD FTVRGDKLWL HTEHGLLVSM AEYRSELLCT
     SAFLGYSAVF LLETEDAVTQ VRLSDLRLKH RCGIVKADNL LHFALCTVIS CVENCNLTRK
     CLHDLLQYLD AVNVRESFGR LLHHSARRLI CSALYLLFEE KEPHIVQYVP ATFVLFQQTR
     HTCLQLVARF FFRLTGQDEA HSFSLKLTER KTVDGWPVGL GLLDVLNANY PNLPSPPKLP
     PRWERGEEE