ID   CEP1_HCMVM              Reviewed;         249 AA.
AC   F5HA10;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 27.
DE   RecName: Full=Cytoplasmic envelopment protein 1 {ECO:0000255|HAMAP-Rule:MF_04038};
GN   Name=UL103;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Towne;
RX   PubMed=21345947; DOI=10.1128/jvi.01682-10;
RA   Ahlqvist J., Mocarski E.;
RT   "Cytomegalovirus UL103 controls virion and dense body egress.";
RL   J. Virol. 85:5125-5135(2011).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_04038, ECO:0000269|PubMed:21345947}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04038}. Virion
CC       tegument {ECO:0000255|HAMAP-Rule:MF_04038}. Host cytoplasm
CC       {ECO:0000255|HAMAP-Rule:MF_04038, ECO:0000269|PubMed:21345947}. Host
CC       Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_04038,
CC       ECO:0000269|PubMed:21345947}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 1 family. {ECO:0000255|HAMAP-Rule:MF_04038}.
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DR   EMBL; AY446894; AAR31653.1; -; Genomic_DNA.
DR   RefSeq; YP_081549.1; NC_006273.2.
DR   PRIDE; F5HA10; -.
DR   GeneID; 3077559; -.
DR   KEGG; vg:3077559; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   HAMAP; MF_04038; HSV_CEP1; 1.
DR   InterPro; IPR002600; Herpes_UL7.
DR   Pfam; PF01677; Herpes_UL7; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..249
FT                   /note="Cytoplasmic envelopment protein 1"
FT                   /id="PRO_0000418241"
SQ   SEQUENCE   249 AA;  28636 MW;  A8D9F8F89F02FE9D CRC64;
     MEALMIRGVL EVHTDFTRQN VMIMEPQVLD FTVRGDKLWL HTEHGLLVSM AEYRSELLCT
     SAFLGYSAVF LLETEDAVTQ VRLSDLRLKH RCGIVKADNL LHFALCTVIS CVENCNLTRK
     CLHDLLQYLD AVNVRESFGR LLHHSARRLI CSALYLLFEE KEPHIVQYVP ATFVLFQQTR
     HTCLQLVARF FFRLTGQDEA HSFSLKLTER KTVDGWPVGL GLLDVLNANY PNLPSPPKLP
     PRWERGEEE