ID   CEP1_HHV6U              Reviewed;         249 AA.
AC   P52456;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-JUN-2021, entry version 56.
DE   RecName: Full=Cytoplasmic envelopment protein 1 {ECO:0000255|HAMAP-Rule:MF_04038};
GN   Name=U75; Synonyms=HDLF2;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7941342; DOI=10.1006/viro.1994.1589;
RA   Nicholas J.;
RT   "Nucleotide sequence analysis of a 21-kbp region of the genome of human
RT   herpesvirus-6 containing homologues of human cytomegalovirus major
RT   immediate-early and replication genes.";
RL   Virology 204:738-750(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_04038}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04038}. Virion
CC       tegument {ECO:0000255|HAMAP-Rule:MF_04038}. Host cytoplasm
CC       {ECO:0000255|HAMAP-Rule:MF_04038}. Host Golgi apparatus
CC       {ECO:0000255|HAMAP-Rule:MF_04038}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 1 family. {ECO:0000255|HAMAP-Rule:MF_04038}.
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DR   EMBL; U13194; AAA68466.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58367.1; -; Genomic_DNA.
DR   RefSeq; NP_042968.1; NC_001664.2.
DR   PRIDE; P52456; -.
DR   DNASU; 1487957; -.
DR   GeneID; 1487957; -.
DR   KEGG; vg:1487957; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04038; HSV_CEP1; 1.
DR   InterPro; IPR002600; Herpes_UL7.
DR   Pfam; PF01677; Herpes_UL7; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..249
FT                   /note="Cytoplasmic envelopment protein 1"
FT                   /id="PRO_0000115918"
SQ   SEQUENCE   249 AA;  28761 MW;  F23EB88CECEDBCB8 CRC64;
     MKSLKKLKEL ETSDVFNILH VRTILKVIKI DKCISLARHP LVNITVGDDG IWFHLEDGTM
     INGLEYKTIC EKELGFQGFI GIIILDSEDT LQELRLNPFQ FKRRLIHMKV DTPEEFMLCG
     LVFALENLPL KQSTLHKLIA KLVLFPALSP ITKILFNTCD TLVCTLRHIF FNEHASEILH
     KVPLMIRLYN EMKNTHIEVL ELYFNTKRSH NFINLSLESR QLQDSSLQVI QLATQFAQTF
     YSKNGDTSS