ID   CEP1_HHV6Z              Reviewed;         249 AA.
AC   P52457;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 60.
DE   RecName: Full=Cytoplasmic envelopment protein 1 {ECO:0000255|HAMAP-Rule:MF_04038};
GN   Name=U75; Synonyms=CB2L;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8634027; DOI=10.1007/bf01718406;
RA   Lindquester G.J., Inoue N., Allen R.D., Castelli J.W., Stamey F.R.,
RA   Dambaugh T.R., O'Brian J.J., Danovich R.M., Frenkel N., Pellett P.E.;
RT   "Restriction endonuclease mapping and molecular cloning of the human
RT   herpesvirus 6 variant B strain Z29 genome.";
RL   Arch. Virol. 141:367-379(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_04038}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04038}. Virion
CC       tegument {ECO:0000255|HAMAP-Rule:MF_04038}. Host cytoplasm
CC       {ECO:0000255|HAMAP-Rule:MF_04038}. Host Golgi apparatus
CC       {ECO:0000255|HAMAP-Rule:MF_04038}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 1 family. {ECO:0000255|HAMAP-Rule:MF_04038}.
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DR   EMBL; AF157706; AAB06358.1; -; Genomic_DNA.
DR   PIR; T44220; T44220.
DR   RefSeq; NP_050254.1; NC_000898.1.
DR   PRIDE; P52457; -.
DR   DNASU; 1497075; -.
DR   GeneID; 1497075; -.
DR   KEGG; vg:1497075; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04038; HSV_CEP1; 1.
DR   InterPro; IPR002600; Herpes_UL7.
DR   Pfam; PF01677; Herpes_UL7; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..249
FT                   /note="Cytoplasmic envelopment protein 1"
FT                   /id="PRO_0000115919"
SQ   SEQUENCE   249 AA;  28862 MW;  C3AD82F2F2860B35 CRC64;
     MKSLKKLKEL ETSDVFNTLH VRTILKVIKI DKCVSLARHS LVNITVGDDG IWFHLEDGTM
     INGLEYKTIC EKELGFQGFI GIIILDSEDT LQELRLNPFQ FKRRLIHMKV DTPEEFMLCG
     LVFALENLPL KQSTLHKLIA RLVLFPVLSP VTKILFNTCD KLVCTLRHIF FNEHASEILH
     KVPPMIRLYN EMKNTHIEVL ELYFNTKRSH NFINLSLESR QLQDSSLQVI QLATQFAQIF
     YSKNEDTSS