ID   ACD17_MYCTU             Reviewed;         409 AA.
AC   P95280; F2GGT1; I6X2Q0; L0T9P1;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Putative acyl-CoA dehydrogenase FadE17 {ECO:0000305};
DE            EC=1.3.99.- {ECO:0000305};
GN   Name=fadE17; OrderedLocusNames=Rv1934c;
GN   ORFNames=LH57_10525 {ECO:0000312|EMBL:AIR14679.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INDUCTION.
RX   PubMed=19389781; DOI=10.1099/mic.0.027086-0;
RA   de la Paz Santangelo M., Klepp L., Nunez-Garcia J., Blanco F.C., Soria M.,
RA   Garcia-Pelayo M.C., Bianco M.V., Cataldi A.A., Golby P., Jackson M.,
RA   Gordon S.V., Bigi F.;
RT   "Mce3R, a TetR-type transcriptional repressor, controls the expression of a
RT   regulon involved in lipid metabolism in Mycobacterium tuberculosis.";
RL   Microbiology 155:2245-2255(2009).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000250|UniProtKB:Q2LQN9};
CC   -!- INDUCTION: Repressed by Mce3R. {ECO:0000269|PubMed:19389781}.
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CP009480; AIR14679.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44701.1; -; Genomic_DNA.
DR   RefSeq; NP_216450.1; NC_000962.3.
DR   RefSeq; WP_003900438.1; NZ_NVQJ01000034.1.
DR   AlphaFoldDB; P95280; -.
DR   SMR; P95280; -.
DR   STRING; 83332.Rv1934c; -.
DR   PaxDb; P95280; -.
DR   DNASU; 885379; -.
DR   GeneID; 885379; -.
DR   KEGG; mtu:Rv1934c; -.
DR   PATRIC; fig|83332.111.peg.2152; -.
DR   TubercuList; Rv1934c; -.
DR   eggNOG; COG1960; Bacteria.
DR   HOGENOM; CLU_018204_9_0_11; -.
DR   OMA; ANSPACW; -.
DR   PhylomeDB; P95280; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   Gene3D; 1.10.540.10; -; 1.
DR   Gene3D; 2.40.110.10; -; 1.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR   InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR   InterPro; IPR036250; AcylCo_DH-like_C.
DR   InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR   InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR   SUPFAM; SSF47203; SSF47203; 1.
DR   SUPFAM; SSF56645; SSF56645; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..409
FT                   /note="Putative acyl-CoA dehydrogenase FadE17"
FT                   /id="PRO_0000438538"
SQ   SEQUENCE   409 AA;  44684 MW;  790FDE8F76959544 CRC64;
     MDVSYPPEAE AFRDRIREFV AEHLPPGWPG PGALPPHERE EFARHWRRAL AGAGLVAVSW
     PTEYGGGGLS PMEQVVLAEE FARAGAPERA ENDLLGIDLL GNTLIALGSE AQKRHFLPRI
     LSGEHRWCQG FSEPEAGSDL ASVRTRGVLD GDEWVINGHK IWTSAGTTAN WIFLLARTDP
     SAAKHRGLSF LLVPMDQPGV VVRPIVNAAG HSSFSEVFLT DARTSAGNVV GRVGDGWSTA
     MTLLGFERGS HIATAAIDFE RDLQRLCELA RDRGLHTDPR VRDGLAWCYA RVQIMRYRGY
     RDLTLALTGR PPGAEAAITK VIWSEYFRRY TDLAVEILGL EALGPRGPGN GGARLVPEAG
     TPNSPACWMD ELLYARAATI YAGSSQIQRN VIGERLLGLP KEPRPEVLC