ID   CEP1_HHV8P              Reviewed;         278 AA.
AC   F5HAI6;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   02-JUN-2021, entry version 24.
DE   RecName: Full=Cytoplasmic envelopment protein 1 {ECO:0000255|HAMAP-Rule:MF_04038};
GN   Name=ORF42;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_04038}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04038}. Virion
CC       tegument {ECO:0000255|HAMAP-Rule:MF_04038}. Host cytoplasm
CC       {ECO:0000255|HAMAP-Rule:MF_04038}. Host Golgi apparatus
CC       {ECO:0000255|HAMAP-Rule:MF_04038}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 1 family. {ECO:0000255|HAMAP-Rule:MF_04038}.
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DR   EMBL; AF148805; ABD28892.1; -; Genomic_DNA.
DR   RefSeq; YP_001129394.1; NC_009333.1.
DR   SMR; F5HAI6; -.
DR   BioGRID; 1776943; 1.
DR   PRIDE; F5HAI6; -.
DR   DNASU; 4961440; -.
DR   GeneID; 4961440; -.
DR   KEGG; vg:4961440; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04038; HSV_CEP1; 1.
DR   InterPro; IPR002600; Herpes_UL7.
DR   Pfam; PF01677; Herpes_UL7; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..278
FT                   /note="Cytoplasmic envelopment protein 1"
FT                   /id="PRO_0000423800"
SQ   SEQUENCE   278 AA;  31225 MW;  1206A1893811EE46 CRC64;
     MSLERALARL TGVPMSTHAP KTRESEEACP VYPHPVVPRL VLEVHRKNNA LVGSNTPKMS
     VMGHLDIACL REHVKSRLSS PNFVGFTVVC LVEHEDMVTH IDLHPHVFQE RVCLLRPTSP
     GITELCCLLS MLENCRDMSP TFLRSIICRA RKTHERTPGM DAAFVMHGIE TLTATAAFVY
     ELSVDDHFRA TPLVMFKLHK AIGDASTPMG GLMKPIYLES FKLESSGENE DDKQTCADPV
     NIFYCDTIFT KHLENNEVLK YLKMCTLFKP PIVSLFSK