ID   CEP1_VZVD               Reviewed;         331 AA.
AC   P09301;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-DEC-2020, entry version 55.
DE   RecName: Full=Cytoplasmic envelopment protein 1 {ECO:0000255|HAMAP-Rule:MF_04038};
GN   Name=ORF53;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
RN   [2]
RP   FUNCTION, INTERACTION WITH PROTEIN ORF7, AND SUBCELLULAR LOCATION.
RX   PubMed=29116592; DOI=10.1007/s12250-017-4048-x;
RA   Wang W., Fu W., Pan D., Cai L., Ye J., Liu J., Liu C., Que Y., Xia N.,
RA   Zhu H., Cheng T.;
RT   "Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its
RT   trans-Golgi network localization.";
RL   Virol. Sin. 32:387-395(2017).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_04038, ECO:0000269|PubMed:29116592}.
CC   -!- SUBUNIT: Interacts with protein ORF7; this interaction localizes
CC       protein ORF53 to the host trans-Golgi network (TGN).
CC       {ECO:0000269|PubMed:29116592}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04038}. Virion
CC       tegument {ECO:0000255|HAMAP-Rule:MF_04038}. Host cytoplasm
CC       {ECO:0000255|HAMAP-Rule:MF_04038}. Host Golgi apparatus
CC       {ECO:0000255|HAMAP-Rule:MF_04038, ECO:0000269|PubMed:29116592}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 1 family. {ECO:0000255|HAMAP-Rule:MF_04038}.
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DR   EMBL; X04370; CAA27936.1; -; Genomic_DNA.
DR   PIR; A27215; WZBE53.
DR   SMR; P09301; -.
DR   PRIDE; P09301; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04038; HSV_CEP1; 1.
DR   InterPro; IPR002600; Herpes_UL7.
DR   Pfam; PF01677; Herpes_UL7; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host Golgi apparatus; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..331
FT                   /note="Cytoplasmic envelopment protein 1"
FT                   /id="PRO_0000115921"
SQ   SEQUENCE   331 AA;  37419 MW;  31DCD45521D7F8EF CRC64;
     MQRIRPYWIK FEQTGGAGMA DGMSGINIPS ILGCSVTIDN LLTRAEEGLD VSDVIEDLRI
     QAIPRFVCEA REVTGLKPRF LANSVVSLRV KPEHQETVLV VLNGDSSEVS CDRYYMECVT
     QPAFRGFIFS VLTAVEDRVY TVGVPPRLLI YRMTLFRPDN VLDFTLCVIL MYLEGIGPSG
     ASPSLFVQLS VYLRRVECQI GPLEKMRRFL YEGVLWLLNT LMYVVDNNPF TKTRVLPHYM
     FVKLLNPQPG TAPNIIKAIY SCGVGQRFDL PHGTPPCPDG VVQVPPGLLN GPLRDSEYQK
     SVYFWWLNRT MVTPKNVQLF ETYKNSPRVV K