ID   CEP2_ALHV1              Reviewed;         335 AA.
AC   O36382;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   02-DEC-2020, entry version 46.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=33;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; AF005370; AAC58079.1; -; Genomic_DNA.
DR   PIR; T03127; T03127.
DR   RefSeq; NP_065531.1; NC_002531.1.
DR   PRIDE; O36382; -.
DR   GeneID; 911796; -.
DR   KEGG; vg:911796; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..335
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000405741"
SQ   SEQUENCE   335 AA;  37276 MW;  9F3F317D7DD06EB3 CRC64;
     MGSRERRWLL KHFLNKECLW VKNSASTAVI KVYTSTTARS PLWPGRHAAM PGIEGPINVT
     VQLMKPKDRK MCATFYVNGV FVDSCTPTAF YCREVQRYGI YLLFFGDLVD PEPPNVIPEN
     IAVHKNEPPV HLTILQMVNS ATLLKTPDDL PKPHVEVVPL GPFGPWMANG SLLQYTINPD
     LLICCPSIGT LPTMSNIITW ITKCENEECE SCHGNSDHAC VLRGVTLADQ NYGSDTCPCV
     APCSMRHGNI ARITTSSNLL GFLFPPESQN DIVAIRAKSN KLTLNVQDIF CGVTREGEEV
     ACLQSPWLLF GLSHLVSRMV MYGCESIKRK CLRSY