ID   CEP2_EBVA8              Reviewed;         336 AA.
AC   P0CK54; P03221; Q777C8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   02-JUN-2021, entry version 20.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   ORFNames=BGLF2;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; DQ279927; ABB89265.1; -; Genomic_DNA.
DR   RefSeq; YP_001129486.1; NC_009334.1.
DR   RefSeq; YP_401691.1; NC_007605.1.
DR   PRIDE; P0CK54; -.
DR   DNASU; 3783768; -.
DR   GeneID; 3783768; -.
DR   GeneID; 5176204; -.
DR   KEGG; vg:3783768; -.
DR   KEGG; vg:5176204; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..336
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000415971"
SQ   SEQUENCE   336 AA;  36888 MW;  840937A416D5584C CRC64;
     MASAANSSRE QLRKFLNKEC LWVLSDASTP QMKVYTATTA VSAVYVPQIA GPPKTYMNVT
     LIVLKPKKKP TYVTVYINGT LATVARPEVL FTKAVQGPHS LTLMYFGVFS DAVGEAVPVE
     IRGNPVVTCT DLTTAHVFTT STAVKTVEEL QDITPSEIIP LGRGGAWYAE GALYMFFVNM
     DMLMCCPNMP TFPSLTHFIN LLTRCDNGEC VTCYGAGAHV NILRGWTEDD SPGTSGTCPC
     LLPCTALNND YVPITGHRAL LGLMFKPEDA PFVVGLRFNP PKMHPDMSRV LQGVLANGKE
     VPCTAQPWTL LRFSDLYSRA MLYNCQVLKR QVLHSY