ID   CEP2_EBVB9              Reviewed;         336 AA.
AC   P0CK53; P03221; Q777C8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   02-JUN-2021, entry version 28.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   ORFNames=BGLF2;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1662696; DOI=10.1099/0022-1317-72-12-3047;
RA   Chen M.R., Hsu T.Y., Lin S.W., Chen J.Y., Yang C.S.;
RT   "Cloning and characterization of cDNA clones corresponding to transcripts
RT   from the BamHI G region of the Epstein-Barr virus genome and expression of
RT   BGLF2.";
RL   J. Gen. Virol. 72:3047-3055(1991).
RN   [3]
RP   IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX   PubMed=15534216; DOI=10.1073/pnas.0407320101;
RA   Johannsen E., Luftig M., Chase M.R., Weicksel S., Cahir-McFarland E.,
RA   Illanes D., Sarracino D., Kieff E.;
RT   "Proteins of purified Epstein-Barr virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16286-16291(2004).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- INTERACTION:
CC       P0CK53; A0A0C7TRZ7: BSLF1; Xeno; NbExp=2; IntAct=EBI-2621010, EBI-2621017;
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-Rule:MF_04039,
CC       ECO:0000269|PubMed:15534216}. Host cytoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04039}.
CC       Note=Localizes in the host nucleus up to 18 hours postinfection, but at
CC       later times localizes to punctate, cytoplasmic structures.
CC       {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; M60514; AAA45871.1; -; mRNA.
DR   EMBL; AJ507799; CAD53441.1; -; Genomic_DNA.
DR   EMBL; V01555; CAA24831.1; -; Genomic_DNA.
DR   EMBL; S77132; AAB21113.1; -; mRNA.
DR   PIR; C43044; QQBE40.
DR   RefSeq; YP_401691.1; NC_007605.1.
DR   BioGRID; 971810; 1.
DR   IntAct; P0CK53; 6.
DR   DNASU; 3783768; -.
DR   GeneID; 3783768; -.
DR   KEGG; vg:3783768; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..336
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000115955"
SQ   SEQUENCE   336 AA;  36888 MW;  840937A416D5584C CRC64;
     MASAANSSRE QLRKFLNKEC LWVLSDASTP QMKVYTATTA VSAVYVPQIA GPPKTYMNVT
     LIVLKPKKKP TYVTVYINGT LATVARPEVL FTKAVQGPHS LTLMYFGVFS DAVGEAVPVE
     IRGNPVVTCT DLTTAHVFTT STAVKTVEEL QDITPSEIIP LGRGGAWYAE GALYMFFVNM
     DMLMCCPNMP TFPSLTHFIN LLTRCDNGEC VTCYGAGAHV NILRGWTEDD SPGTSGTCPC
     LLPCTALNND YVPITGHRAL LGLMFKPEDA PFVVGLRFNP PKMHPDMSRV LQGVLANGKE
     VPCTAQPWTL LRFSDLYSRA MLYNCQVLKR QVLHSY