ID   CEP2_EHV1B              Reviewed;         370 AA.
AC   P28970; Q6DLG4;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   29-SEP-2021, entry version 74.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   OrderedLocusNames=46;
OS   Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31520;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA   Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-1.";
RL   Virology 189:304-316(1992).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; AY665713; AAT67304.1; -; Genomic_DNA.
DR   PIR; B36800; WZBED9.
DR   RefSeq; YP_053092.1; NC_001491.2.
DR   PRIDE; P28970; -.
DR   GeneID; 1487538; -.
DR   KEGG; vg:1487538; -.
DR   Proteomes; UP000001189; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..370
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000115952"
SQ   SEQUENCE   370 AA;  40802 MW;  91CEB48505D99C68 CRC64;
     MMAAASDSCL SLWEGSASSP NRQLTPEAVN CLTEALTEDV AVLRLIRSDP RVKIFMAVSV
     LTPRLARFAP PPPKLTHTAK CAVIMIYLTR PKALALQPKQ FHMLVTFNKA SVYSLVVRVK
     TKPFPVGTQR FRAVFQDPEF IGLPSDIPDP AAENIPTEIN DRLDVSNFAT PAQPPKDKYD
     CCVLAPGVWW SNANKAIYFL QMDVALLALC PAGWKARGLG IILGRLLNHQ EGCATCRFTE
     HSDPLNATAD SVATPESCLC WAPCLWRKAH QRELTVEGDR YLFRVLFMDA VERVRLTGLR
     RSPKITANLA DLVVGIGPHG QQIPVNNAGW KLVALDADIS RLIVCGCYAL RYICPPTNSK
     HQPSSPDEYA