ID   CEP2_EHV2               Reviewed;         341 AA.
AC   Q66636;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-DEC-2020, entry version 49.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=33;
OS   Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82831;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA   Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus 2.";
RL   J. Mol. Biol. 249:520-528(1995).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; U20824; AAC13820.1; -; Genomic_DNA.
DR   PIR; S55627; S55627.
DR   RefSeq; NP_042629.1; NC_001650.2.
DR   GeneID; 1461046; -.
DR   KEGG; vg:1461046; -.
DR   Proteomes; UP000007083; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..341
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000406062"
SQ   SEQUENCE   341 AA;  37759 MW;  9495115578380C7F CRC64;
     MASGGVGGTR ELFRQFLNKE CIWKKSPNSS PYLKIYVATT AISPVFKPDV GGRGRPGSAH
     AINVTALFMK PKGRRTCAAF YVNGLLLEAC VPEVIFTKVV PGVLGLFLIY FGPFAEPRRP
     FPIPTEPAIS APQNVQLLNR MEMLDTSTHI ALSDLGEAVA GREFTSVGKL VWWDGEAFFF
     YYLSMEYMMC CPTISEHTTL SRFITLLTQC DDRGCVPCHG RKIHANVAGG YTDPGSDGVS
     TTCLCTLSCA ALEKELVPVT KNKSLLSLMF GPMTYQQVTH LRFTPSTRPA RIQDIISGVT
     ETGDRVDVRD GTWNLLKMSS LYSRCTLYEC QILKRQCLRS Y