ID   CEP2_GAHVM              Reviewed;         360 AA.
AC   Q9E6Q1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   02-DEC-2020, entry version 55.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=MDV028;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; AF243438; AAG14208.1; -; Genomic_DNA.
DR   RefSeq; YP_001033944.1; NC_002229.3.
DR   GeneID; 4811489; -.
DR   KEGG; vg:4811489; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..360
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000406560"
SQ   SEQUENCE   360 AA;  41311 MW;  0879A6B092F05B2B CRC64;
     MTTQRLKIPR STRHQHSGRD CDGMDIEFVR RLNERIIIWR TLRAESRLVV MLALIALDSS
     LCTYVTPNKQ PRKAKWVEIF MYLTRPKNLY LSRKEFHILF LANGTRAYSV TATLRIHPIL
     HEGSSADVIF FSNVSSTEAY AIIPDVTSEF LPTTPCIELD IDVFVERTQP PDDPHNCIPI
     SIGVWWSFSK RRFYYLRMEE SLLAICPAGW QQRSLSATLA KFINHESGCR ECREHCDLHI
     DAYNVLWECG SFGHTCLCRG PCMWIKARQR DLLVEGDKSL GCVLFMDMVN SVRLITNPST
     ETRITERLED VIVAGVGYSN IPVNSCGWHL VCLPEIWSAI MIQGCIRLTR LCNDRQPNVV