ID   CEP2_HCMVM              Reviewed;         345 AA.
AC   F5HAC7;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=UL94;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating (By similarity). Additionally, antagonizes the viral
CC       DNA-triggered antiviral immune response by targeting host STING1 and
CC       preventing its dimerization and trafficking.
CC       {ECO:0000250|UniProtKB:P16800, ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid (By similarity). Interacts with host STING1; this interaction
CC       prevents viral DNA-triggered antiviral immune response (By similarity).
CC       {ECO:0000250|UniProtKB:P16800, ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; AY446894; AAR31645.1; -; Genomic_DNA.
DR   RefSeq; YP_081541.1; NC_006273.2.
DR   PRIDE; F5HAC7; -.
DR   DNASU; 3077496; -.
DR   GeneID; 3077496; -.
DR   KEGG; vg:3077496; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Late protein;
KW   Reference proteome; Viral immunoevasion; Virion; Virion tegument.
FT   CHAIN           1..345
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000417840"
FT   REGION          26..35
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000250|UniProtKB:P16800"
FT   REGION          55..63
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:P16800"
FT   REGION          90..94
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000250|UniProtKB:P16800"
SQ   SEQUENCE   345 AA;  38294 MW;  B0046B59FEFC2401 CRC64;
     MAWRSGLCET DSRTLKQFLQ EECMWKLVGK SRKHREYRAV ACRSTIFSPE DDGSCILCQL
     LLFYRDGEWI LCLCCNGRYQ GHYGVGHVHR RRRRICHLPT LYQLSFGGPL GPASIDFLPS
     FSQVTSSMTC DGITPDVIYE VCMLVPQDEA KRILVKGHGA MDLTCQKAVT LGGAGAWLLP
     RPEGYTLFFY ILCYDLFTSC GNRCDIPSMT RLMAAATACG QAGCSFCTDH EGHVDPTGNY
     VGCTPDMGRC LCYVPCGPMT QSLIHNEEPA TFFCESDDAK YLCAVGSKTA AQVTLGDGLD
     YHIGVKDSEG RWLPVKTDVW DLVKVEEPVS RMIVCSCPVL KNLVH