ID   CEP2_HHV2H              Reviewed;         372 AA.
AC   P89439;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 56.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=UL16;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA   McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT   "Comparative sequence analysis of the long repeat regions and adjoining
RT   parts of the long unique regions in the genomes of herpes simplex viruses
RT   types 1 and 2.";
RL   J. Gen. Virol. 72:3057-3075(1991).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=9645194; DOI=10.1007/s007050050338;
RA   Oshima S., Daikoku T., Shibata S., Yamada H., Goshima F., Nishiyama Y.;
RT   "Characterization of the UL16 gene product of herpes simplex virus type
RT   2.";
RL   Arch. Virol. 143:863-880(1998).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039,
CC       ECO:0000269|PubMed:9645194}. Host nucleus {ECO:0000255|HAMAP-
CC       Rule:MF_04039, ECO:0000269|PubMed:9645194}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; Z86099; CAB06776.1; -; Genomic_DNA.
DR   PRIDE; P89439; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..372
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000406176"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..35
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40120 MW;  55B298BB8370A5CB CRC64;
     MAQRALWRPQ ATPGPPGAAA PPGHRGAPPD ARAPDPGPEA DLVARIANSV FVWRVVRGDE
     RLKIFRCLTV LTEPLCQVAL PDPDPERALF CEIFLYLTRP KALRLPSNTF FAIFFFNRER
     RYCATVHLRS VTHPRTPLLC TLAFGHLEAA SPPEETPDPA AEQLADEPVA HELDGAYLVP
     TDTAPESGAC CALGPGAWWH LPGGRIYCWA MDDDLGSLCP PGSRARHLGW LLSRITDPPG
     GGGACAPTAH IDSANALWRA PAVAEACPCV APCMWSNMAQ RTLAVRGDAS LCQLLFGHPV
     DAVILRQATR RPRITAHLHE VVVGRDGAES VIRPTSAGWR LCVLSSYTSR LFATSCPAVA
     RAVARASSSD YK