ID   CEP2_HHV6U              Reviewed;         335 AA.
AC   P24442;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   23-FEB-2022, entry version 73.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=U65; Synonyms=11R;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2152817; DOI=10.1128/jvi.64.1.287-299.1990;
RA   Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W.,
RA   Barrell B.G.;
RT   "Human herpesvirus 6 is closely related to human cytomegalovirus.";
RL   J. Virol. 64:287-299(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; X83413; CAA58357.1; -; Genomic_DNA.
DR   EMBL; M68963; AAA65574.1; -; Genomic_DNA.
DR   PIR; B36769; B36769.
DR   RefSeq; NP_042958.1; NC_001664.2.
DR   PRIDE; P24442; -.
DR   DNASU; 1487947; -.
DR   GeneID; 1487947; -.
DR   KEGG; vg:1487947; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..335
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000115950"
SQ   SEQUENCE   335 AA;  37877 MW;  177BC8ED39DEE014 CRC64;
     MAISTFSIGD LGYLRNFLQN ECNWFRICKK TFYREYRSVA TSSPTFSLNN KPKKFCMHCE
     IVIFKRSEEF MFSLAVNGIH FGQFLTGKMK FNKKAVPEGL YYYILELGSI TPIDLGFIPR
     YNSDCVTNMR CVTPEVIYEN CSIVCPEEAN RLTVKGSGDN KLTPLGGCGA WCLKNGGDLY
     IYTFALAYDL FLTCYDKSTF PSLAKIIFDM IACESEDCVF CKDHNKHVSQ AGQIVGCVSN
     QETCFCYTSC KKKMANINNP ELISLLCDQE INKIDIMYPK IKASLSLDIN SYAHGYFGDD
     PYALKCVNWI PVRISAALSR LIVLSCPVCK RVVMD