ID   CEP2_HHV6Z              Reviewed;         335 AA.
AC   Q9QJ19;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-JUN-2021, entry version 41.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=U65;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z29;
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; AF157706; AAD49666.1; -; Genomic_DNA.
DR   RefSeq; NP_050245.1; NC_000898.1.
DR   PRIDE; Q9QJ19; -.
DR   DNASU; 1497065; -.
DR   GeneID; 1497065; -.
DR   KEGG; vg:1497065; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..335
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000408433"
SQ   SEQUENCE   335 AA;  37878 MW;  B83D7529E320F8A4 CRC64;
     MAISTFSIGD LGYLRNFLQN ECNWFRICKK TFYREYRSVA TSSPIFSLKN KPKKYCMHCE
     MVVLKRSHEF MFSLAVNGIH FGQFLTGIMK FKKKQVAEGL CYYVLELGSI SPVDLSFIPK
     YNSDCVTSMH CVTPELIYEN CSIVCPEEAS RLTVKGLGDN KLIPLGGCGV WCLKNGGDLY
     IYAFVLAYDL YVACYDKTIF PSLAKIVFDM IACDSEDCVF CKDHNKHVSQ AGHIVGCVSN
     QETCFCYTPC QKKMTDINNP ELISLLCDQE INKIDIMYPE KKASLSLDIN SYVHGYLGDE
     PCALKCVNWM PIRISSALSR LIILSCPVCK RVVMD